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Rabbit Anti-GADD45GIP1 Recombinant Antibody (EG1278) (CBMAB-EN1542-LY)

The product is antibody recognizes GADD45GIP1. The antibody EG1278 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:40000.
See all GADD45GIP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1278
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GADD45GIP1.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GADD45G Interacting Protein 1
Introduction
This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
Entrez Gene ID
90480
UniProt ID
Q8TAE8
Alternative Names
GADD45G Interacting Protein 1; Growth Arrest And DNA-Damage-Inducible, Gamma Interacting Protein 1; Mitochondrial Large Ribosomal Subunit Protein ML64; Papillomavirus L2 Interacting Nuclear Protein 1; 39S Ribosomal Protein L59, Mitochondrial; CKII Beta-Associating Protein; P53-Responsive Gene 6 Protein; CKII Beta Binding Protein 2; CR6 Interacting Factor 1; MRP-L59; PLINP-1; Plinp1; CRIF1;
Function
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
Biological Process
Cell cycle Source: UniProtKB-KW
Regulation of cell cycle Source: GO_Central
Cellular Location
Mitochondrion; Nucleus. Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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