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Mouse Anti-GAP43 Recombinant Antibody (CBFYH-3423) (CBMAB-H3969-FY)

This product is mouse antibody that recognizes GAP43. The antibody CBFYH-3423 can be used for immunoassay techniques such as: IHC, WB.
See all GAP43 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYH-3423
Antibody Isotype
IgG
Application
IHC, WB

Basic Information

Immunogen
GAP-43 protein from neonatal rat forebrain membranes
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Growth Associated Protein 43
Introduction
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Entrez Gene ID
29423
UniProt ID
P07936
Alternative Names
Basp2
Function
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Biological Process
Axon choice point recognition Source: GO_Central
Axon regeneration Source: GO_Central
Cell fate commitment Source: Ensembl
Glial cell differentiation Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of filopodium assembly Source: UniProtKB
Regulation of growth Source: UniProtKB-KW
Regulation of postsynaptic specialization assembly Source: Ensembl
Response to wounding Source: ProtInc
Tissue regeneration Source: GO_Central
Cellular Location
Cytoplasm; Cell membrane; Growth cone membrane; Filopodium membrane; Synapse; Perikaryon; Dendrite; Axon. Cytoplasmic surface of growth cone and synaptic plasma membranes.
PTM
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216). Deacylated by LYPLA2 (PubMed:21152083).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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