GAP43
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Full Name
Growth Associated Protein 43
Alternative Names
Growth Associated Protein 43; Axonal Membrane Protein GAP-43; Neural Phosphoprotein B-50; Neuron Growth-Associated Protein 43; Nerve Growth-Related Peptide GAP43; Calmodulin-Binding Protein P-57;
Function
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Biological Process
Axon choice point recognition Source: GO_Central
Axon regeneration Source: GO_Central
Cell fate commitment Source: Ensembl
Glial cell differentiation Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of filopodium assembly Source: UniProtKB
Regulation of growth Source: UniProtKB-KW
Regulation of postsynaptic specialization assembly Source: Ensembl
Response to wounding Source: ProtInc
Tissue regeneration Source: GO_Central
Axon regeneration Source: GO_Central
Cell fate commitment Source: Ensembl
Glial cell differentiation Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of filopodium assembly Source: UniProtKB
Regulation of growth Source: UniProtKB-KW
Regulation of postsynaptic specialization assembly Source: Ensembl
Response to wounding Source: ProtInc
Tissue regeneration Source: GO_Central
Cellular Location
Cytoplasm; Cell membrane; Growth cone membrane; Filopodium membrane; Synapse; Perikaryon; Dendrite; Axon. Cytoplasmic surface of growth cone and synaptic plasma membranes.
PTM
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216). Deacylated by LYPLA2 (PubMed:21152083).
Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216). Deacylated by LYPLA2 (PubMed:21152083).
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Anti-GAP43 antibodies
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CompareTarget: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 14C1
Application*: E, WB, IH
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT590
Application*: WB, P, IF
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC160
Application*: WB, P
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 6F2
Application*: IHC, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP807
Application*: ELISA, IHC, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB254A
Application*: ELISA, WB, IHC
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Chicken, Human, Mouse, Rat
Clone: GAP-8A12
Application*: ELISA, WB, IHC
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB223
Application*: WB, IHC
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBWJN-0606
Application*: P, IH-F, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1000
Application*: WB, IC, P, C, E
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYH-3423
Application*: IH, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-539
Application*: WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-537
Application*: IH, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: CBLG1-536
Application*: E, C, P, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-535
Application*: WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-534
Application*: IC, IF, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Chicken, Human, Mouse, Rabbit, Rat, Snake
Clone: CBLG1-532
Application*: E, C, P, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: CBLG1-530
Application*: IF, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat, Chicken, Human, Mouse, Rabbit, Snake
Clone: CBLG1-529
Application*: P/F, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-528
Application*: P, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-527
Application*: WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLG1-525
Application*: IH, IP, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBLG1-523
Application*: C, P, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgM
Specificity: Chicken
Clone: CBLG1-521
Application*: F
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-520
Application*: P, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLG1-519
Application*: IH, IP, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat
Clone: CBLG1-518
Application*: WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: CBLG1-517
Application*: E, C, P, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-516
Application*: IC, IF, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: M333
Application*: WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Rat, Chicken, Human, Cat, Snake
Clone: GAP-7B10
Application*: WB
Target: GAP43
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D9C8
Application*: WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat, Chicken, Human, Mouse
Clone: 9G366
Application*: IH, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Chicken, Human, Mouse, Rabbit, Rat, Reptile
Clone: 7B10
Application*: E, IH, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C11
Application*: E, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human
Clone: 2Q55
Application*: IH, IP, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G7
Application*: IH
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 15H198
Application*: IC, IF, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat
Clone: 13B824
Application*: IF, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Chicken, Human, Mouse
Clone: 10K231
Application*: IH, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: CBLG1-034
Application*: E, IH, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: CBLG1-2568
Application*: WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0237
Application*: WB, IF
Target: GAP43
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBLNG-181
Application*: WB, E, IH
Target: GAP43
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: Mix
Application*: P, WB
Target: GAP43
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse, Chicken, Human, Snake
Clone: GAP-8A12
Application*: C, P, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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