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Mouse Anti-GAP43 Recombinant Antibody (Mix) (CBMAB-1559-CN)

This product is a mouse antibody that recognizes GAP43 of human. The antibody Mix can be used for immunoassay techniques such as: IHC-P, WB.
See all GAP43 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
Mix
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Immunogen
Recombinant Protein
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% Glycerol, 0.5% BSA
Preservative
0.02% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Growth Associated Protein 43
Introduction
GAP43 is considered a crucial component of an effective regenerative response in the nervous system. GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration.
Entrez Gene ID
Human2596
Mouse14432
Rat29423
UniProt ID
HumanP17677
MouseP06837
RatP07936
Alternative Names
B-50; PP46
Function
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Biological Process
Axon choice point recognition Source: GO_Central
Axon regeneration Source: GO_Central
Cell fate commitment Source: Ensembl
Glial cell differentiation Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of filopodium assembly Source: UniProtKB
Regulation of growth Source: UniProtKB-KW
Regulation of postsynaptic specialization assembly Source: Ensembl
Response to wounding Source: ProtInc
Tissue regeneration Source: GO_Central
Cellular Location
Cytoplasm; Cell membrane; Growth cone membrane; Filopodium membrane; Synapse; Perikaryon; Dendrite; Axon. Cytoplasmic surface of growth cone and synaptic plasma membranes.
PTM
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction (PubMed:14978216). Deacylated by LYPLA2 (PubMed:21152083).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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