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Mouse Anti-GAS8 Recombinant Antibody (CBLG1-2596) (CBMAB-G2162-LY)

This product is antibody recognizes GAS8. The antibody CBLG1-2596 immunoassay techniques such as: WB.
See all GAS8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2596
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human GAS8 (NP_001472) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Growth Arrest Specific 8
Introduction
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Entrez Gene ID
2622
UniProt ID
O95995
Alternative Names
Growth Arrest Specific 8; Growth Arrest-Specific Protein 11; GAS-11; GAS11; Growth Arrest-Specific Protein 8; Growth Arrest-Specific 11; CILD33; GAS-8; DRC4;
Function
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity).

Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning (PubMed:26387594, PubMed:27120127, PubMed:27472056).

Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner (By similarity).
Biological Process
Axoneme assembly Source: UniProtKB
Cellular protein localization Source: GO_Central
Cilium movement involved in cell motility Source: GO_Central
Flagellated sperm motility Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Positive regulation of protein localization to cilium Source: UniProtKB
Positive regulation of smoothened signaling pathway Source: UniProtKB
Regulation of microtubule binding Source: UniProtKB
Cellular Location
Cytoskeleton; Cilium axoneme; Cilium basal body; Flagellum axoneme; Golgi apparatus; Cytoplasm; Flagellum; Cilium. Associates with microtubules (PubMed:10969087). Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa (By similarity).
Involvement in disease
Ciliary dyskinesia, primary, 33 (CILD33):
A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD33 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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