Mouse Anti-GATAD1 Recombinant Antibody (1D3) (CBMAB-1433-YC)

Name: Mouse Anti-GATAD1 Recombinant Antibody (1D3)
SKU: CBMAB-1433-YC
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-GATAD1 Recombinant Antibody (1D3) (CBMAB-1433-YC) in IHC

Case with positive EMSY staining in A was stained for other EMSY/KDM5A complex members. ZNF131, GATAD1, and KDM5A correlated positively with the EMSY status whereas SIN3B correlated negatively. The example in A that was negative for EMSY expression, was also negative for ZNF131, GATAD1, KDM5A, and SIN3B (data not shown), thus revealing a positive expression correlation between the EMSY/KDM5A complex subunits in primary breast cancer. ...View More

Varier, R. A., Carrillo de Santa Pau, E., van der Groep, P., Lindeboom, R. G., Matarese, F., Mensinga, A., Smits, A. H., Edupuganti, R. R., Baltissen, M. P., Jansen, P. W., Ter Hoeve, N., van Weely, D. R., Poser, I., van Diest, P. J., Stunnenberg, H. G., & Vermeulen, M. (2016). Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. The Journal of biological chemistry, 291(14), 7313-7324.

Datasheet

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Basic Information

Host Animal

Mouse

Clone

1D3

Application

WB, IF, FC, IP

Immunogen

C-terminal region of human GATAD1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.1 mg/ml

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GATA Zinc Finger Domain Containing 1

Introduction

GATAD1 contains a zinc finger at the N-terminus, and is thought to bind to a histone modification site that regulates gene expression. Mutations in GATAD1 have been associated with autosomal recessive dilated cardiomyopathy.

Entrez Gene ID

Human	57798
Mouse	67210

UniProt ID

Human	Q8WUU5
Mouse	Q920S3

Function

Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3).

Biological Process

Chromatin organization Source: GO_Central
Chromatin remodeling Source: GO_Central
Regulation of transcription, DNA-templated Source: InterPro

Cellular Location

Nucleus

Involvement in disease

Cardiomyopathy, dilated 2B (CMD2B):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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