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Mouse Anti-GATAD2B Recombinant Antibody (CBFYH-0261) (CBMAB-H1134-FY)

This product is mouse antibody that recognizes GATAD2B. The antibody CBFYH-0261 can be used for immunoassay techniques such as: ELISA, WB.
See all GATAD2B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0261
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
GATA zinc finger domain containing 2B
Introduction
This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability.
Entrez Gene ID
57459
UniProt ID
Q8WXI9
Alternative Names
GATA Zinc Finger Domain Containing 2B; Transcription Repressor P66 Beta Component Of The MeCP1 Complex; GATA Zinc Finger Domain-Containing Protein 2B; Transcriptional Repressor P66-Beta; KIAA1150; P66beta; P66/P68; MRD18; P68
Function
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.
Biological Process
ATP-dependent chromatin remodeling Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus speckle. Speckled nuclear localization requires both CR1 and CR2 regions.
Involvement in disease
Mental retardation, autosomal dominant 18 (MRD18):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD18 patients have severe intellectual disability and dysmorphic features.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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