GATAD2B

GATAD2B is a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability.
Full Name
GATA zinc finger domain containing 2B
Function
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development.
Biological Process
ATP-dependent chromatin remodeling Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus speckle. Speckled nuclear localization requires both CR1 and CR2 regions.
Involvement in disease
Mental retardation, autosomal dominant 18 (MRD18):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD18 patients have severe intellectual disability and dysmorphic features.
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Anti-GATAD2B antibodies

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Mouse Anti-GATAD2B Recombinant Antibody (CBLG1-703) (V2LY-1225-LY788)

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Target: GATAD2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat, Monkey
Clone: CBLG1-703
Application*: WB
Datasheet SDS

Mouse Anti-GATAD2B Recombinant Antibody (CBFYH-0261) (V2LY-1225-LY787)

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Target: GATAD2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-0261
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-GATAD2B Recombinant Antibody (CBLG1-703) (CBMAB-G2321-LY)

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Target: GATAD2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-703
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-GATAD2B Recombinant Antibody (CBFYH-0261) (CBMAB-H1134-FY)

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Target: GATAD2B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0261
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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