Mouse Anti-GATM Recombinant Antibody (CBLG1-2625) (V2LY-1225-LY795)

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Basic Information

Host Animal
Mouse
Clone
CBLG1-2625
Application
WB, IHC, IF, FC
Immunogen
Full length human recombinant protein of human GATM.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
ApplicationNote
WB1:2,000
IF(ICC)1:100
IHC1:150
FC1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, BSA, glycerol
Preservative
Sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Glycine Amidinotransferase
Entrez Gene ID
UniProt ID
Function
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Biological Process
Creatine biosynthetic process Source: MGI
Creatine metabolic process Source: CAFA
Learning or memory Source: CAFA
Multicellular organism development Source: CAFA
Muscle atrophy Source: CAFA
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Cellular Location
Isoform 1: Mitochondrion inner membrane. Probably attached to the outer side of the inner membrane.
Isoform 2: Cytoplasm
Involvement in disease
Cerebral creatine deficiency syndrome 3 (CCDS3):
An autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, and severe depletion of creatine/phosphocreatine in the brain. Most patients develop a myopathy characterized by muscle weakness and atrophy later in life.
Fanconi renotubular syndrome 1 (FRTS1):
A form of Fanconi renotubular syndrome, a disease due to a generalized dysfunction of the proximal kidney tubule resulting in decreased solute and water reabsorption. Patients have polydipsia and polyuria with phosphaturia, glycosuria and aminoaciduria. They may develop hypophosphatemic rickets or osteomalacia, acidosis and a tendency toward dehydration. Some eventually develop renal insufficiency. FRTS1 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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