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Mouse Anti-GCLC Recombinant Antibody (CBLG1-805) (CBMAB-G2636-LY)

This product is antibody recognizes GCLC. The antibody CBLG1-805 immunoassay techniques such as: WB.
See all GCLC antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human
Clone
CBLG1-805
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Rat, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutamate-cysteine ligase, catalytic subunit
Introduction
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
Entrez Gene ID
Human2729
Rat25283
UniProt ID
HumanP48506
RatP19468
Biological Process
Aging Source: Ensembl
Blood vessel diameter maintenance Source: UniProtKB
Cell redox homeostasis Source: UniProtKB
Cellular response to fibroblast growth factor stimulus Source: Ensembl
Cellular response to follicle-stimulating hormone stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: Ensembl
Cellular response to insulin stimulus Source: Ensembl
Cellular response to mechanical stimulus Source: Ensembl
Cellular response to thyroxine stimulus Source: Ensembl
Cysteine metabolic process Source: UniProtKB
Glutamate metabolic process Source: UniProtKB
Glutathione biosynthetic process Source: UniProtKB
L-ascorbic acid metabolic process Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of hepatic stellate cell activation Source: Ensembl
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of protein ubiquitination Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
Regulation of mitochondrial depolarization Source: Ensembl
Response to activity Source: Ensembl
Response to arsenic-containing substance Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to heat Source: UniProtKB
Response to hormone Source: UniProtKB
Response to human chorionic gonadotropin Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to nitrosative stress Source: Ensembl
Response to nutrient Source: Ensembl
Response to oxidative stress Source: UniProtKB
Response to xenobiotic stimulus Source: Ensembl
Cellular Location
Cytosol; Mitochondrion; Glutamate-cysteine ligase complex
Involvement in disease
Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD):
A disease characterized by hemolytic anemia, glutathione deficiency, myopathy, late-onset spinocerebellar degeneration, and peripheral neuropathy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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