Sign in or Register   Sign in or Register
  |  

Mouse Anti-GCSAM Recombinant Antibody (1E9) (CBMAB-A3328-LY)

The product is antibody recognizes GCET2. The antibody 1E9 immunoassay techniques such as: WB, ELISA.
See all GCSAM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E9
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
GCET2 (AAH30506, 1 a.a. ~ 178 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Germinal Center Associated Signaling And Motility
Introduction
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
Entrez Gene ID
257144
UniProt ID
Q8N6F7
Alternative Names
GCAT2; HGAL; MGC40441
Function
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Biological Process
Negative regulation of lymphocyte migration Source: UniProtKB
Regulation of B cell receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm. It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
PTM
Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-GCSAM Recombinant Antibody (1E9)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare