GCSAM

GCSAM is a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4.

Full Name

Germinal Center Associated Signaling And Motility

Function

Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.

Biological Process

Negative regulation of lymphocyte migration Source: UniProtKB
Regulation of B cell receptor signaling pathway Source: UniProtKB

Cellular Location

Cell membrane; Cytoplasm. It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.

PTM

Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.

Anti-GCSAM antibodies

Mouse Anti-GCSAM Recombinant Antibody (ABM43E6) (CBMAB-G2666-LY)

Datasheet

SDS

Target: GCSAM

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: ABM43E6

Application*: P

Rabbit Anti-GCSAM Recombinant Antibody (CBLG1-2685) (CBMAB-G2667-LY)

Datasheet

SDS

Target: GCSAM

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-2685

Application*: P, F

Mouse Anti-GCSAM Recombinant Antibody (MRQ-49) (CBMAB-G2668-LY)

Datasheet

SDS

Target: GCSAM

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MRQ-49

Application*: C, P

Mouse Anti-GCSAM Recombinant Antibody (CBLG1-815) (CBMAB-G2670-LY)

Datasheet

SDS

Target: GCSAM

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-815

Application*: WB

Mouse Anti-GCSAM Recombinant Antibody (CBLG1-816) (CBMAB-G2671-LY)

Datasheet

SDS

Target: GCSAM

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBLG1-816

Application*: E, WB

Mouse Anti-GCSAM Recombinant Antibody (1E9) (CBMAB-A3328-LY)

Datasheet

SDS

Target: GCSAM

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E9

Application*: WB, E

Mouse Anti-GCSAM Recombinant Antibody (IHC598) (CBMAB-MA102-YC)

Datasheet

SDS

Target: GCSAM

Host: Mouse

Specificity: Human

Clone: IHC598

Application*: IH

Mouse Anti-GCSAM Recombinant Antibody (CBFYH-0296) (CBMAB-H0576-FY)

Datasheet

SDS

Target: GCSAM

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0296

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)