GCSAM

GCSAM is a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4.
Full Name
Germinal Center Associated Signaling And Motility
Function
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Biological Process
Negative regulation of lymphocyte migration Source: UniProtKB
Regulation of B cell receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm. It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
PTM
Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.
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Anti-GCSAM antibodies

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Mouse Anti-GCSAM Recombinant Antibody (1E9) (CBMAB-A3328-LY)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E9
Application*: IH
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (IHC598) (CBMAB-MA102-YC)

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Target: GCSAM
Host: Mouse
Specificity: Human
Clone: IHC598
Application*: IH
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (CBLG1-816) (CBMAB-G2671-LY)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-816
Application*: E, WB
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (CBLG1-815) (CBMAB-G2670-LY)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-815
Application*: WB
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (MRQ-49) (CBMAB-G2668-LY)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MRQ-49
Application*: C, P
Datasheet SDS

Rabbit Anti-GCSAM Recombinant Antibody (CBLG1-2685) (CBMAB-G2667-LY)

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Target: GCSAM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2685
Application*: P, F
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (3E6) (CBMAB-G2666-LY)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3E6
Application*: IH
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (CBFYH-0296) (CBMAB-H0576-FY)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0296
Application*: E, WB
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (CBLG1-816) (V2LY-1225-LY944)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-816
Application*: IH
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (CBLG1-815) (V2LY-1225-LY943)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-815
Application*: WB, E
Datasheet SDS

Mouse Anti-GCSAM Recombinant Antibody (G2668) (V2LY-1225-LY942)

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Target: GCSAM
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: G2668
Application*: IH
Datasheet SDS

Rabbit Anti-GCSAM Recombinant Antibody (CBLG1-2685) (V2LY-1225-LY941)

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Target: GCSAM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2685
Application*: IH, IF, F
Datasheet SDS

Rabbit Anti-GCSAM Recombinant Antibody (CBFYH-0296) (V2LY-1225-LY939)

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Target: GCSAM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-0296
Application*: WB, IF, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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