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Rabbit Anti-GCSAM Recombinant Antibody (CBLG1-2685) (CBMAB-G2667-LY)

This product is antibody recognizes GCSAM. The antibody CBLG1-2685 immunoassay techniques such as: IHC-P, FC.
See all GCSAM antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLG1-2685
Antibody Isotype
IgG
Application
IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1.187 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Germinal Center Associated Signaling And Motility
Introduction
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
257144
UniProt ID
Q8N6F7
Alternative Names
Germinal Center Associated Signaling And Motility; Germinal Center B-Cell-Expressed Transcript 2 Protein; Germinal Center-Associated Lymphoma Protein; Human Germinal Center-Associated Lymphoma; Germinal Center Expressed Transcript 2; GCET2;
Function
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Biological Process
Negative regulation of lymphocyte migration Source: UniProtKB
Regulation of B cell receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane; Cytoplasm. It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
PTM
Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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