Mouse Anti-GDF7 (AA 204-301) Recombinant Antibody (CBFYH-0309) (CBMAB-H1180-FY)

Name: Mouse Anti-GDF7 (AA 204-301) Recombinant Antibody (CBFYH-0309)
SKU: CBMAB-H1180-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-0309

Application

ELISA

Immunogen

Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Immunogen sequence: VGQRWEAFDV ADAMRRHRRE PRPPRAFCLL LRAVAGPVPS PLALRRLGFG WPGGGGSAAE ERAVLVVSSR TQRKESLFRE IRAQARALGA ALASEPLP

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 204-301

More Infomation

Target

Full Name

Growth Differentiation Factor 7

Introduction

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma.

Entrez Gene ID

151449

UniProt ID

Q7Z4P5

Alternative Names

Growth Differentiation Factor 7; GDF-7; Growth/Differentiation Factor 7; BMP12

Function

May play an active role in the motor area of the primate neocortex.

Biological Process

Activin receptor signaling pathway Source: BHF-UCL
Axon guidance Source: Ensembl
BMP signaling pathway Source: BHF-UCL
Branching morphogenesis of an epithelial tube Source: Ensembl
Cell fate commitment Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Forebrain morphogenesis Source: Ensembl
Gland morphogenesis Source: Ensembl
Midbrain development Source: Ensembl
Morphogenesis of an epithelial fold Source: Ensembl
Pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of tendon cell differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Reproductive structure development Source: Ensembl
Roof plate formation Source: Ensembl
SMAD protein signal transduction Source: GO_Central
Spinal cord association neuron differentiation Source: Ensembl

Cellular Location

Secreted

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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