GDF7

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]
Full Name
Growth Differentiation Factor 7
Function
May play an active role in the motor area of the primate neocortex.
Biological Process
Activin receptor signaling pathway Source: BHF-UCL
Axon guidance Source: Ensembl
BMP signaling pathway Source: BHF-UCL
Branching morphogenesis of an epithelial tube Source: Ensembl
Cell fate commitment Source: Ensembl
Epithelial cell differentiation Source: Ensembl
Forebrain morphogenesis Source: Ensembl
Gland morphogenesis Source: Ensembl
Midbrain development Source: Ensembl
Morphogenesis of an epithelial fold Source: Ensembl
Pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of gene expression Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of tendon cell differentiation Source: Ensembl
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Reproductive structure development Source: Ensembl
Roof plate formation Source: Ensembl
SMAD protein signal transduction Source: GO_Central
Spinal cord association neuron differentiation Source: Ensembl
Cellular Location
Secreted
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Anti-GDF7 antibodies

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Rabbit Anti-GDF7 Recombinant Antibody (EG1304) (CBMAB-EN1576-LY)

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Target: GDF7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1304
Application*: WB: 1:500~1:1000 ELISA: 1:40000
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (1H1) (CBMAB-A3369-LY)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H1
Application*: WB, E
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (CBLG1-837) (CBMAB-G2760-LY)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-837
Application*: E, WB
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (CBLG1-836) (CBMAB-G2759-LY)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-836
Application*: E, WB
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (CBLG1-835) (CBMAB-G2758-LY)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-835
Application*: WB
Datasheet SDS

Mouse Anti-GDF7 (AA 361-450) Recombinant Antibody (CBFYH-0310) (CBMAB-H1181-FY)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0310
Application*: E, WB
Datasheet SDS

Rat Anti-GDF7 Recombinant Antibody (CBFYH-0309) (CBMAB-H1180-FY)

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Target: GDF7
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0309
Application*: N
Functional Assay
Datasheet SDS

Human GDF7 ELISA Kit (V2LY-0626-LY4643)

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Target: GDF7
Sensitivity: 0.014 ng/mL
Detection Range: 0.03-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Gdf7 ELISA Kit (V2LY-0626-LY2391)

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Target: Gdf7
Sensitivity: 0.00088 ng/mL
Detection Range: 0.002-0.7 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (1H1) (V2LY-1225-LY1017)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1H1
Application*: E
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (CBLG1-2695) (V2LY-1225-LY1016)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-2695
Application*: WB, E
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (CBLG1-837) (V2LY-1225-LY1015)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-837
Application*: WB, E
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (CBLG1-836) (V2LY-1225-LY1014)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-836
Application*: E
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (CBLG1-835) (V2LY-1225-LY1013)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-835
Application*: E
Datasheet SDS

Mouse Anti-GDF7 Recombinant Antibody (CBFYH-0310) (V2LY-1225-LY1012)

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Target: GDF7
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-0310
Application*: WB, E
Datasheet SDS

Rabbit Anti-GDF7 Recombinant Antibody (CBLG1-2695) (CBMAB-G2757-LY)

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Target: GDF7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLG1-2695
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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