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Rat Anti-GFAP Monoclonal Antibody (2.2B10) (CBMAB-1329-YC)

Provided herein is a rat monoclonal antibody against Bovine GFAP. The antibody, clone 2.2B10, can be used for immunoassay techniques, such as IF, IHC, FC, IP, ELISA and WB.
See all GFAP antibodies
Published Data
Fig.1 Mice injected with AAV2-miSyn4 had similar numbers of TH+ and GFAP+ cells by immunohistochemistry compared to uninjected sides or AAV-eGFP mice.
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Fig.2 Astrocyte markers GFAP (green) in naïve hOMSC constructs.
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Fig.3 Representative images showing immunohistochemical (IHC) staining for GFAP.
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Summary

Host Animal
Rat
Specificity
Cattle, Guinea pig, Human, Mouse, Rat
Clone
2.2B10
Antibody Isotype
IgG2a, κ
Application
IF, IHC, FC, IP, ELISA, WB

Basic Information

Immunogen
Enriched bovine glial filaments
Specificity
Cattle, Guinea pig, Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glial Fibrillary Acidic Protein
Introduction
GFAP is one of the major intermediate filament proteins of mature astrocytes, which is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in GFAP cause Alexander disease, a rare disorder of astrocytes in the central nervous system.
Entrez Gene ID
Human2670
Mouse14580
Rat24387
Guinea pig100720409
Cattle281189
UniProt ID
HumanP14136
MouseP03995
RatP47819
Guinea pigH0W8R6
CattleQ28115
Alternative Names
ALXDRD
Function
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Biological Process
Astrocyte development Source: Ensembl
Bergmann glial cell differentiation Source: Ensembl
D-aspartate import across plasma membrane Source: Ensembl
Extracellular matrix organization Source: Ensembl
Gene expression Source: Ensembl
Intermediate filament organization Source: UniProtKB
Intracellular protein transport Source: Ensembl
Long-term synaptic potentiation Source: Ensembl
Negative regulation of neuron projection development Source: Ensembl
Neuron projection regeneration Source: Ensembl
Positive regulation of Schwann cell proliferation Source: Ensembl
Regulation of chaperone-mediated autophagy Source: ParkinsonsUK-UCL
Regulation of neurotransmitter uptake Source: Ensembl
Regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
Response to wounding Source: Ensembl
Cellular Location
Cytoplasm. Associated with intermediate filaments.
Involvement in disease
Alexander disease (ALXDRD):
A rare disorder of the central nervous system. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death within the first decade. Infants with Alexander disease develop a leukodystrophy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes.
PTM
Phosphorylated by PKN1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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