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Mouse Anti-GFM2 Recombinant Antibody (CBFYE-1453) (CBMAB-E2081-FY)

This product is mouse antibody that recognizes GFM2. The antibody CBFYE-1453 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all GFM2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYE-1453
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
G Elongation Factor Mitochondrial 2
Introduction
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Entrez Gene ID
Human84340
Mouse320806
Rat294672
UniProt ID
HumanQ969S9
MouseQ8R2Q4
RatQ5BJP6
Alternative Names
G Elongation Factor Mitochondrial 2; MEF-G 2; EF-G2mt; RRF2mt; HEFG2; EFG2; Ribosome-Releasing Factor 2, Mitochondrial; Mitochondrial Ribosome Recycling Factor 2
Function
Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
Biological Process
Mitochondrial translation Source: UniProtKB
Mitochondrial translational termination Source: Reactome
Ribosome disassembly Source: UniProtKB
Translational elongation Source: GOC
Cellular Location
Mitochondrion
Involvement in disease
Combined oxidative phosphorylation deficiency 39 (COXPD39):
An autosomal recessive disorder due to mitochondrial dysfunction and characterized by global developmental delay, axial hypotonia, dystonia, dysarthria, impaired intellectual development with poor speech, and deficiencies of the mitochondrial respiratory chain enzyme complexes. Neuroimaging shows abnormalities in the putamen and caudate nuclei, along with subcortical white matter involvement.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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