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Mouse Anti-GH1 Recombinant Antibody (CBLG1-1098) (CBMAB-G3356-LY)

This product is antibody recognizes GH1. The antibody CBLG1-1098 immunoassay techniques such as: WB.
See all GH1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBLG1-1098
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Growth Hormone
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Growth Hormone 1
Introduction
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.
Entrez Gene ID
24391
UniProt ID
P01244
Alternative Names
Gh; Ghb1; RNGHGP
Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Biological Process
Animal organ development Source: GO_Central
Bone maturation Source: BHF-UCL
Growth hormone receptor signaling pathway Source: BHF-UCL
Positive regulation of activation of Janus kinase activity Source: BHF-UCL
Positive regulation of glucose transmembrane transport Source: MGI
Positive regulation of growth Source: GO_Central
Positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of MAP kinase activity Source: BHF-UCL
Positive regulation of multicellular organism growth Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: BHF-UCL
Response to estradiol Source: BHF-UCL
Response to nutrient levels Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Growth hormone deficiency, isolated, 1A (IGHD1A):
An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone.
Growth hormone deficiency, isolated, 1B (IGHD1B):
An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.
Kowarski syndrome (KWKS):
A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy.
Growth hormone deficiency, isolated, 2 (IGHD2):
An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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