GH1
Growth hormone (GH) or somatotropin, also known as humangrowth hormone (hGH or HGH) in its human form, is a peptidehormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals. It is thus important in human development.
Full Name
Growth Hormone 1
Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Biological Process
Animal organ development Source: GO_Central
Bone maturation Source: BHF-UCL
Growth hormone receptor signaling pathway Source: BHF-UCL
Positive regulation of activation of Janus kinase activity Source: BHF-UCL
Positive regulation of glucose transmembrane transport Source: MGI
Positive regulation of growth Source: GO_Central
Positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of MAP kinase activity Source: BHF-UCL
Positive regulation of multicellular organism growth Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: BHF-UCL
Response to estradiol Source: BHF-UCL
Response to nutrient levels Source: GO_Central
Bone maturation Source: BHF-UCL
Growth hormone receptor signaling pathway Source: BHF-UCL
Positive regulation of activation of Janus kinase activity Source: BHF-UCL
Positive regulation of glucose transmembrane transport Source: MGI
Positive regulation of growth Source: GO_Central
Positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of MAP kinase activity Source: BHF-UCL
Positive regulation of multicellular organism growth Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: BHF-UCL
Response to estradiol Source: BHF-UCL
Response to nutrient levels Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Growth hormone deficiency, isolated, 1A (IGHD1A):
An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone.
Growth hormone deficiency, isolated, 1B (IGHD1B):
An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.
Kowarski syndrome (KWKS):
A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy.
Growth hormone deficiency, isolated, 2 (IGHD2):
An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone.
Growth hormone deficiency, isolated, 1B (IGHD1B):
An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.
Kowarski syndrome (KWKS):
A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy.
Growth hormone deficiency, isolated, 2 (IGHD2):
An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
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Anti-GH1 antibodies
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CompareTarget: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1100
Application*: E, P
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: g3H5
Application*: WB, E
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP837
Application*: ICC, IHC, IP, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: g3H5
Application*: Dot blot, ELISA, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP836
Application*: Dot blot, ELISA
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB319A
Application*: ELISA
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5944
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYH-3433
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1106
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1105
Application*: IO
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1104
Application*: E (IA)
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1102
Application*: E, P, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1099
Application*: WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-1098
Application*: WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1091
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1090
Application*: E, R
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1088
Application*: IF, P, IP, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1085
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1084
Application*: E, P, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1083
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1082
Application*: P, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1081
Application*: IC, P
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-1075
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1073
Application*: IC, P
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1071
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1070
Application*: IF, P, IP, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-1065
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1064
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1062
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1061
Application*: E, P
Target: GH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: YC6
Application*: IA, EC, R
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: PG3H5AT
Application*: E (IA), WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M12619GH1
Application*: E, IA
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M0410181
Application*: E, WB
Target: GH1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: KT19
Application*: E, SE
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Gh297C8
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GH-15
Application*: E, IH
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GH-1
Application*: WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GA-8
Application*: P
Target: GH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2758
Application*: WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 8J33
Application*: WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C8
Application*: IA
Target: GH1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 6J33
Application*: N, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E615
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H284
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 16k134
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10K232
Application*: IF, IH, IP, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 090-12210
Application*: IA/E
Target: GH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-095
Application*: IH, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-094
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: YC8
Application*: IA
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: SPM106
Application*: F
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GhB9
Application*: E, SE
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: GH-45
Application*: IH, IC/IF, P
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Gh29
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: GH01/2+GH02/7
Application*: P, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4k9
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E2
Application*: E, IP, R
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 222517
Application*: WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 178902
Application*: WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 12K264
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Horse, Human
Clone: CBFYH-0347
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0345
Application*: IH, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0344
Application*: E, IA
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0342
Application*: E, IP, R
Target: GH1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: KT34
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: GH/1371
Application*: F, P, IF
Target: GH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0343
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0348
Application*: F, IF, P
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2519
Application*: F
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBLG1-1063
Application*: E, WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBLG1-3167
Application*: WB
Target: GH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle
Clone: 8.F.23
Application*: E
Target: GH1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Horse, Human
Clone: 5B4
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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