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Mouse Anti-GH1 (AA 27-217) Recombinant Antibody (g3H5) (CBMAB-H0120-FY)

This product is mouse antibody that recognizes GH1. The antibody g3H5 can be used for immunoassay techniques such as: WB, ELISA.
See all GH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
g3H5
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human Growth Hormone protein purified from E. coli
Specificity
Human, Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 27-217

Target

Full Name
Growth Hormone 1
Introduction
The present study was carried out to investigate the possible association of the polymorphism at GH1 and POU1F1 loci with meat production traits in Piemontese cattle.
Entrez Gene ID
2688
UniProt ID
P01241
Alternative Names
Growth Hormone 1; Pituitary Growth Hormone; Somatotropin; GH-N; GH; Growth Hormone B5
Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Biological Process
Animal organ development Source: GO_Central
Bone maturation Source: BHF-UCL
Growth hormone receptor signaling pathway Source: BHF-UCL
Positive regulation of activation of Janus kinase activity Source: BHF-UCL
Positive regulation of glucose transmembrane transport Source: MGI
Positive regulation of growth Source: GO_Central
Positive regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Positive regulation of MAP kinase activity Source: BHF-UCL
Positive regulation of multicellular organism growth Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: BHF-UCL
Response to estradiol Source: BHF-UCL
Response to nutrient levels Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Growth hormone deficiency, isolated, 1A (IGHD1A):
An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone.
Growth hormone deficiency, isolated, 1B (IGHD1B):
An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.
Kowarski syndrome (KWKS):
A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy.
Growth hormone deficiency, isolated, 2 (IGHD2):
An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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