Mouse Anti-GH2 Recombinant Antibody (1E11) (CBMAB-G3366-LY)

growth hormone 2

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]
GH2 (Growth Hormone 2) is a Protein Coding gene.
Diseases associated with GH2 include Choriocarcinoma and Prostate Carcinoma In Situ.
Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PAK Pathway.
Gene Ontology (GO) annotations related to this gene include hormone activity.
An important paralog of this gene is GH1.
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Growth Hormone 2; Placenta-Specific Growth Hormone; Placental-Specific Growth Hormone; GH-V; Growth Hormone Variant; Growth Hormone B2;

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Animal organ development Source: GO_Central
Growth hormone receptor signaling pathway Source: GO_Central
Positive regulation of growth Source: GO_Central
Positive regulation of receptor signaling pathway via JAK-STAT Source: GO_Central
Positive regulation of tyrosine phosphorylation of STAT protein Source: GO_Central
Response to nutrient levels Source: GO_Central

Secreted