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GH2

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq]
Full Name
growth hormone 2
Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Biological Process
Animal organ development Source: GO_Central
Growth hormone receptor signaling pathway Source: GO_Central
Positive regulation of growth Source: GO_Central
Positive regulation of receptor signaling pathway via JAK-STAT Source: GO_Central
Positive regulation of tyrosine phosphorylation of STAT protein Source: GO_Central
Response to nutrient levels Source: GO_Central
Cellular Location
Secreted
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Anti-GH2 antibodies

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Mouse Anti-GH2 Recombinant Antibody (CBFYH-2914) (CBMAB-H1218-FY)

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Target: GH2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-2914
Application*: P
Datasheet SDS

Mouse Anti-GH2 Recombinant Antibody (CBLG1-1110) (CBMAB-G3369-LY)

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Target: GH2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-1110
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-GH2 Recombinant Antibody (CBLG1-1109) (CBMAB-G3368-LY)

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Target: GH2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-1109
Application*: WB
Datasheet SDS

Mouse Anti-GH2 Recombinant Antibody (1E11) (CBMAB-G3366-LY)

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Target: GH2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E11
Application*: E, WB
Datasheet SDS

Mouse Anti-GH2 Recombinant Antibody (YC6) (CBMAB-H1220-FY)

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Target: GH2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: YC6
Application*: E
Datasheet SDS

Mouse Anti-GH2 Monoclonal Antibody (CBFYH-2973) (CBMAB-H1219-FY)

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Target: GH2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2973
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-GH2 Recombinant Antibody (YC8) (CBMAB-H0339-FY)

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Target: GH2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: YC8
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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