Mouse Anti-GHR Recombinant Antibody (3C59) (V2LY-1225-LY1262)
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Basic Information
| Application | Note |
| WB | 1 μg/ml |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
Cartilage development involved in endochondral bone morphogenesis Source: Ensembl
Cellular response to hormone stimulus Source: BHF-UCL
Cellular response to insulin stimulus Source: Ensembl
Cytokine-mediated signaling pathway Source: GO_Central
Endocytosis Source: UniProtKB-KW
Growth hormone receptor signaling pathway Source: BHF-UCL
Hormone-mediated signaling pathway Source: Ensembl
Hormone metabolic process Source: BHF-UCL
Insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of neuron death Source: Ensembl
Positive regulation of cell differentiation Source: Ensembl
Positive regulation of MAP kinase activity Source: BHF-UCL
Positive regulation of multicellular organism growth Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: GO_Central
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Receptor internalization Source: BHF-UCL
Receptor signaling pathway via JAK-STAT Source: BHF-UCL
Regulation of multicellular organism growth Source: BHF-UCL
Response to cycloheximide Source: BHF-UCL
Response to estradiol Source: BHF-UCL
Response to food Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to morphine Source: Ensembl
Taurine metabolic process Source: BHF-UCL
Isoform 2: Cell membrane. Remains fixed to the cell membrane and is not internalized.
Growth hormone-binding protein: Secreted. Complexed to a substantial fraction of circulating GH.
A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone.
Growth hormone insensitivity, partial (GHIP):
A disease characterized by partial resistance to growth hormone resulting in short stature. Short stature is defined by a standing height more than 2 standard deviations below the mean (or below the 2.5 percentile) for sex and chronological age, compared with a well-nourished, healthy, genetically relevant population.
Helical: 265-288
Cytoplasmic: 289-638
On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2.
On ligand binding, ubiquitinated on lysine residues in the cytoplasmic domain. This ubiquitination is not sufficient for GHR internalization (By similarity).
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Mouse Anti-GHR Recombinant Antibody (3C59) (CAT#: CBMAB-G3375-LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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