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Mouse Anti-GLDC Recombinant Antibody (F5) (CBMAB-AP2482LY)


See all GLDC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
F5
Antibody Isotype
IgG
Application
ELISA, IHC, WB

Basic Information

Immunogen
Ovalbumin-conjugated synthetic peptide PFSEQKRAS
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glycine Decarboxylase
Introduction
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Entrez Gene ID
2731
UniProt ID
P23378
Alternative Names
Glycine Decarboxylase; Glycine Dehydrogenase (Aminomethyl-Transferring); Glycine Cleavage System Protein P; EC 1.4.4.2; GCSP; Glycine Dehydrogenase (Decarboxylating; Glycine Decarboxylase, Glycine Cleavage System Protein P); Glycine Dehydrogenase (Decarboxylating), Mitochondrial; Glycine Dehydrogenase [Decarboxylating], Mitochondrial;
Function
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).
Biological Process
Glycine catabolic process Source: UniProtKB
Glycine decarboxylation via glycine cleavage system Source: GO_Central
Protein-containing complex assembly Source: Ensembl
Response to lipoic acid Source: UniProtKB
Response to methylamine Source: UniProtKB
Cellular Location
Mitochondrion
Involvement in disease
Non-ketotic hyperglycinemia (NKH):
Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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