Mouse Anti-GLDC Recombinant Antibody (F5) (CBMAB-AP2482LY)

Name: Mouse Anti-GLDC Recombinant Antibody (F5)
SKU: CBMAB-AP2482LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

Application

ELISA, IHC, WB

Immunogen

Ovalbumin-conjugated synthetic peptide PFSEQKRAS

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glycine Decarboxylase

Introduction

Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]

Entrez Gene ID

2731

UniProt ID

P23378

Alternative Names

Glycine Decarboxylase; Glycine Dehydrogenase (Aminomethyl-Transferring); Glycine Cleavage System Protein P; EC 1.4.4.2; GCSP; Glycine Dehydrogenase (Decarboxylating; Glycine Decarboxylase, Glycine Cleavage System Protein P); Glycine Dehydrogenase (Decarboxylating), Mitochondrial; Glycine Dehydrogenase [Decarboxylating], Mitochondrial;

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH).

Biological Process

Glycine catabolic process Source: UniProtKB
Glycine decarboxylation via glycine cleavage system Source: GO_Central
Protein-containing complex assembly Source: Ensembl
Response to lipoic acid Source: UniProtKB
Response to methylamine Source: UniProtKB

Cellular Location

Mitochondrion

Involvement in disease

Non-ketotic hyperglycinemia (NKH):
Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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