Mouse Anti-GLMN Recombinant Antibody (1C12) (V2LY-1225-LY1482)
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Basic Information
| Application | Note |
| ELISA | 1:100-1:1,000 |
| WB | 1:100-1:1,000 |
| IP | 1-2 µg per 100-500 µg of total protein (1 ml of cell lysate) |
| IF(ICC) | 1:50-1:500 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924).
Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924).
Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651).
Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity).
Essential for normal development of the vasculature (PubMed:11845407).
Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281).
Muscle cell differentiation Source: UniProtKB
Negative regulation of cell population proliferation Source: MGI
Negative regulation of T cell proliferation Source: UniProtKB
Neural tube closure Source: Ensembl
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of interleukin-2 production Source: MGI
Positive regulation of phosphorylation Source: UniProtKB
Regulation of gene expression, epigenetic Source: UniProtKB
Regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
Vasculogenesis Source: UniProtKB
Characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Mouse Anti-GLMN Recombinant Antibody (1C12) (CAT#: CBMAB-G3804-LY)
Antibody Pairs
GLMN Matched Antibody Pair (485) (CAT#: APMAB-485LY)
Related Products
Mouse Anti-GLMN Recombinant Antibody (1C12) (CAT#: CBMAB-G3804-LY)
Mouse Anti-GLMN Recombinant Antibody (CBLG1-122) (CAT#: V2LY-1225-LY1481)
GLMN Matched Antibody Pair (485) (CAT#: APMAB-485LY)
Mouse Anti-GLMN Recombinant Antibody (2B5) (CAT#: CBMAB-G3805-LY)
Mouse Anti-GLMN Recombinant Antibody (CBLG1-122) (CAT#: CBMAB-G0516-LY)
Mouse Anti-GLMN Recombinant Antibody (CBLG1-1275) (CAT#: V2LY-1225-LY1483)
GLMN Matched Antibody Pair (486) (CAT#: APMAB-486LY)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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