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Mouse Anti-GLMN Recombinant Antibody (CBLG1-122) (CBMAB-G0516-LY)

This product is antibody recognizes GLMN. The antibody CBLG1-122 immunoassay techniques such as: ELISA, ICC, WB.
See all GLMN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-122
Antibody Isotype
IgG1
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glomulin, FKBP Associated Protein
Introduction
This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Entrez Gene ID
11146
UniProt ID
Q92990
Alternative Names
Glomulin; FKBP Associated Protein; FK506-Binding Protein-Associated Protein; FKBP-Associated Protein; VMGLOM; FAP48; FAP68; FAP;
Function
Isoform 1:
Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924).

Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924).

Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651).

Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (By similarity).

Essential for normal development of the vasculature (PubMed:11845407).

Contributes to the regulation of RPS6KB1 phosphorylation (PubMed:11571281).
Biological Process
Cell surface receptor signaling pathway Source: MGI
Muscle cell differentiation Source: UniProtKB
Negative regulation of cell population proliferation Source: MGI
Negative regulation of T cell proliferation Source: UniProtKB
Neural tube closure Source: Ensembl
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of interleukin-2 production Source: MGI
Positive regulation of phosphorylation Source: UniProtKB
Regulation of gene expression, epigenetic Source: UniProtKB
Regulation of proteasomal ubiquitin-dependent protein catabolic process Source: MGI
Vasculogenesis Source: UniProtKB
Cellular Location
Cul2-RING ubiquitin ligase complex; Cul3-RING ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; Cullin-RING ubiquitin ligase complex; Cytoplasm
Involvement in disease
Glomuvenous malformations (GVMs):
Characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens.
PTM
Phosphorylated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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