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Mouse Anti-GLRA1 Recombinant Antibody (CBLG1-1289) (CBMAB-G3852-LY)

This product is antibody recognizes GLRA1. The antibody CBLG1-1289 immunoassay techniques such as: ELISA, WB.
See all GLRA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1289
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein of human glycine receptor subunit alpha-1 (aa 121-221) with a GST tag
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glycine receptor, alpha 1
Introduction
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]
Entrez Gene ID
2741
UniProt ID
P23415
Alternative Names
Glycine Receptor Alpha 1; Glycine Receptor Strychnine-Binding Subunit; Glycine Receptor 48 KDa Subunit; Glycine Receptor; Alpha 1 (Startle Disease/Hyperekplexia); Glycine Receptor Subunit Alpha-1; Stiff Person Syndrome; HKPX1; STHE;
Function
Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860).

Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272).

Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272).

Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753).

Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272).

Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).

Channel activity is potentiated by ethanol (PubMed:25973519).

Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
Biological Process
Acrosome reaction Source: Ensembl
Action potential Source: Ensembl
Adult walking behavior Source: Ensembl
Cellular response to amino acid stimulus Source: UniProtKB
Cellular response to ethanol Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: UniProtKB
Chloride transport Source: UniProtKB
Inhibitory postsynaptic potential Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Muscle contraction Source: UniProtKB
Negative regulation of transmission of nerve impulse Source: UniProtKB
Nervous system process Source: GO_Central
Neuromuscular process controlling posture Source: Ensembl
Neuropeptide signaling pathway Source: UniProtKB
Positive regulation of acrosome reaction Source: UniProtKB
Regulation of membrane potential Source: MGI
Regulation of respiratory gaseous exchange by nervous system process Source: Ensembl
Response to alcohol Source: UniProtKB
Response to amino acid Source: GO_Central
Righting reflex Source: Ensembl
Signal transduction Source: GO_Central
Startle response Source: UniProtKB
Synaptic transmission, glycinergic Source: UniProtKB
Visual perception Source: Ensembl
Cellular Location
Postsynaptic cell membrane; Cell membrane; Synapse; Perikaryon; Dendrite
Involvement in disease
Hyperekplexia 1 (HKPX1):
A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.
Topology
Extracellular: 29-250
Helical: 251-272
Cytoplasmic: 273-277
Helical: 278-298
Extracellular: 299-309
Helical: 310-330
Cytoplasmic: 331-425
Helical: 426-446
Extracellular: 447-457
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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