Mouse Anti-GLRA1 Recombinant Antibody (CBLG1-1292) (V2LY-1225-LY1514)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272).
Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272).
Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753).
Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272).
Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).
Channel activity is potentiated by ethanol (PubMed:25973519).
Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
Action potential Source: Ensembl
Adult walking behavior Source: Ensembl
Cellular response to amino acid stimulus Source: UniProtKB
Cellular response to ethanol Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: UniProtKB
Chloride transport Source: UniProtKB
Inhibitory postsynaptic potential Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Muscle contraction Source: UniProtKB
Negative regulation of transmission of nerve impulse Source: UniProtKB
Nervous system process Source: GO_Central
Neuromuscular process controlling posture Source: Ensembl
Neuropeptide signaling pathway Source: UniProtKB
Positive regulation of acrosome reaction Source: UniProtKB
Regulation of membrane potential Source: MGI
Regulation of respiratory gaseous exchange by nervous system process Source: Ensembl
Response to alcohol Source: UniProtKB
Response to amino acid Source: GO_Central
Righting reflex Source: Ensembl
Signal transduction Source: GO_Central
Startle response Source: UniProtKB
Synaptic transmission, glycinergic Source: UniProtKB
Visual perception Source: Ensembl
A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.
Helical: 251-272
Cytoplasmic: 273-277
Helical: 278-298
Extracellular: 299-309
Helical: 310-330
Cytoplasmic: 331-425
Helical: 426-446
Extracellular: 447-457
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Mouse Anti-GLRA1 Recombinant Antibody (CBLG1-1292) (CAT#: CBMAB-G3855-LY)
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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