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Mouse Anti-GLRX Recombinant Antibody (CBLG1-1297) (CBMAB-G3868-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1297
Antibody Isotype
IgG1, κ
Application
ELISA, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.01% BSA, 50% glycerol
Preservative
0.03% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutaredoxin (thioltransferase)
Introduction
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
Entrez Gene ID
2745
UniProt ID
P35754
Alternative Names
Glutaredoxin; Thioltransferase-1; Thioltransferase; TTase-1; GRX; Glutaredoxin (Thioltransferase); Glutaredoxin-1; GRX1;
Function
Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Biological Process
Nucleobase-containing small molecule interconversion Source: Reactome
Positive regulation of membrane potential Source: BHF-UCL
Positive regulation of sodium ion transmembrane transporter activity Source: BHF-UCL
Protein deglutathionylation Source: BHF-UCL
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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