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Mouse Anti-GP2 Recombinant Antibody (3G7-H9) (CBMAB-G0647-LY)

This product is antibody recognizes GP2. The antibody 3G7-H9 immunoassay techniques such as: FC.
See all GP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G7-H9
Antibody Isotype
IgG1, κ
Application
FC

Basic Information

Immunogen
Human Fc fusion protein of human GP2 quality except the transmembrane region
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glycoprotein 2
Entrez Gene ID
2813
UniProt ID
P55259
Alternative Names
Glycoprotein 2; Glycoprotein 2 (Zymogen Granule Membrane); ZAP75; Pancreatic Secretory Granule Membrane Major Glycoprotein GP2; Pancreatic Zymogen Granule Membrane Associated Protein GP2; Pancreatic Zymogen Granule Membrane Protein GP-2;
Function
Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.
Biological Process
Antigen transcytosis by M cells in mucosal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Neutrophil migration Source: GO_Central
Cellular Location
Secreted; Cell membrane; Apical cell membrane; Endosome; Zymogen granule membrane; Membrane raft. Secreted, after cleavage, in the pancreatic juice.
PTM
N-glycosylated.

Roggenbuck, D., Goihl, A., Sowa, M., Lopens, S., Rödiger, S., Schierack, P., ... & Laass, M. W. (2023). Human glycoprotein-2 expressed in Brunner glands–A putative autoimmune target and link between Crohn's and coeliac disease. Clinical Immunology, 109214.

Luda, K. M., Da Silva, C., Ahmadi, F., Mowat, A. M., Ohno, H., Kotarsky, K., & Agace, W. W. (2022). Identification and characterization of murine glycoprotein 2‐expressing intestinal dendritic cells. Scandinavian Journal of Immunology, 96(5), e13219.

Uhlig, R., Günther, K., Bröker, N., Gorbokon, N., Lennartz, M., Rico, S. D., ... & Jacobsen, F. (2022). Diagnostic and prognostic role of pancreatic secretory granule membrane major glycoprotein 2 (GP2) immunohistochemistry: A TMA study on 27,681 tumors. Pathology-Research and Practice, 238, 154123.

Wunsch, E., Norman, G. L., Milkiewicz, M., Krawczyk, M., Bentow, C., Shums, Z., ... & Milkiewicz, P. (2021). Anti‐glycoprotein 2 (anti‐GP2) IgA and anti‐neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3‐ANCA): antibodies to predict severe disease, poor survival and cholangiocarcinoma in primary sclerosing cholangitis. Alimentary Pharmacology & Therapeutics, 53(2), 302-313.

Kurashima, Y., Kigoshi, T., Murasaki, S., Arai, F., Shimada, K., Seki, N., ... & Kiyono, H. (2021). Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation. Nature communications, 12(1), 1067.

Lin, Y., Nakatochi, M., Sasahira, N., Ueno, M., Egawa, N., Adachi, Y., & Kikuchi, S. (2021). Glycoprotein 2 in health and disease: lifting the veil. Genes and Environment, 43(1), 1-9.

Kusunose, N., Tsuruta, A., Hamamura, K., Tsurudome, Y., Yoshida, Y., Akamine, T., ... & Ohdo, S. (2020). Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches. Genes to Cells, 25(4), 270-278.

Lucien, F., Lac, V., Billadeau, D. D., Borgida, A., Gallinger, S., & Leong, H. S. (2019). Glypican-1 and glycoprotein 2 bearing extracellular vesicles do not discern pancreatic cancer from benign pancreatic diseases. Oncotarget, 10(10), 1045.

Amanat, F., Duehr, J., Oestereich, L., Hastie, K. M., Ollmann Saphire, E., & Krammer, F. (2018). Antibodies to the glycoprotein GP2 subunit cross-react between Old and New World arenaviruses. MSphere, 3(3), e00189-18.

Tornai, T., Tornai, D., Sipeki, N., Tornai, I., Alsulaimani, R., Fechner, K., ... & Papp, M. (2018). Loss of tolerance to gut immunity protein, glycoprotein 2 (GP2) is associated with progressive disease course in primary sclerosing cholangitis. Scientific reports, 8(1), 399.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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