GP2

GP2 could both bridge two membranes and facilitate their apposition to initiate membrane fusion.
Full Name
Glycoprotein 2
Function
Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.
Biological Process
Antigen transcytosis by M cells in mucosal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Neutrophil migration Source: GO_Central
Cellular Location
Secreted; Cell membrane; Apical cell membrane; Endosome; Zymogen granule membrane; Membrane raft. Secreted, after cleavage, in the pancreatic juice.
PTM
N-glycosylated.
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Anti-GP2 antibodies

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Rat Anti-GP2 Recombinant Antibody (2F11-C3) (CBMAB-G4455-LY)

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Target: GP2
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 2F11-C3
Application*: F
Datasheet SDS

Mouse Anti-GP2 Recombinant Antibody (GP2/1551) (CBMAB-G0648-LY)

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Target: GP2
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: GP2/1551
Application*: F
Datasheet SDS

Mouse Anti-GP2 Recombinant Antibody (3G7-H9) (CBMAB-G0647-LY)

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Target: GP2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3G7-H9
Application*: F
Datasheet SDS

Mouse Anti-GP2 (AA 35-179) Monoclonal Antibody (CBFYH-2977) (CBMAB-H0134-FY)

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Target: GP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2977
Application*: F, IF, P
Datasheet SDS

Mouse Anti-GP2 Recombinant Antibody (GP2/1712) (CBMAB-G0649-LY)

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Target: GP2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: GP2/1712
Application*: F
Datasheet SDS

Mouse Anti-GP2 (AA 35-179) Monoclonal Antibody (CBFYH-2976) (CBMAB-H0133-FY)

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Target: GP2
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: CBFYH-2976
Application*: F, E, IF, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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