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GP2

GP2 could both bridge two membranes and facilitate their apposition to initiate membrane fusion.

Full Name

Glycoprotein 2

Function

Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.

Biological Process

Antigen transcytosis by M cells in mucosal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Neutrophil migration Source: GO_Central

Cellular Location

Secreted; Cell membrane; Apical cell membrane; Endosome; Zymogen granule membrane; Membrane raft. Secreted, after cleavage, in the pancreatic juice.

PTM

N-glycosylated.

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Anti-GP2 antibodies

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Rabbit Anti-GP2 Recombinant Antibody (2F11) (CBMAB-G4455-LY)

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Target: GP2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 2F11

Application*: IH

Mouse Anti-GP2 Recombinant Antibody (51) (CBMAB-G0648-LY)

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Target: GP2

Host: Mouse

Antibody Isotype: IgG2c, κ

Specificity: Human

Clone: 51

Application*: E, WB, IH

Mouse Anti-GP2 Recombinant Antibody (3G7) (CBMAB-G0647-LY)

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Target: GP2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G7

Application*: E, WB, IH

Mouse Anti-GP2 Recombinant Antibody (12) (CBMAB-G0649-LY)

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Target: GP2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 12

Application*: E, WB, IH

Mouse Anti-GP2 Recombinant Antibody (CBFYH-2977) (V2LY-0226-LY609)

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Target: GP2

Host: Mouse

Antibody Isotype: IgG2b, λ

Specificity: Human

Clone: CBFYH-2977

Application*: E, WB, IH

Alpaca Anti-GP2 Recombinant VHH Antibody (CBFYH-2976) (CBMAB-H0133-FY)

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Target: GP2

Host: Alpaca

Antibody Isotype: VHH

Specificity: Human

Clone: CBFYH-2976

Application*: E, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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