GP2

GP2 could both bridge two membranes and facilitate their apposition to initiate membrane fusion.

Glycoprotein 2

Functions as an intestinal M-cells transcytotic receptor specific of type-I-piliated bacteria that participate in the mucosal immune response toward these bacteria. At the apical membrane of M-cells binds fimH, a protein of the bacteria type I pilus tip. Internalizes bound bacteria, like E.coli and S.typhimurium, from the lumen of the intestine and delivers them, through M-cells, to the underlying organized lymphoid follicles where they are captured by antigen-presenting dendritic cells to ellicit a mucosal immune response.

Antigen transcytosis by M cells in mucosal-associated lymphoid tissue Source: UniProtKB
Innate immune response Source: UniProtKB-KW
Neutrophil migration Source: GO_Central

Secreted; Cell membrane; Apical cell membrane; Endosome; Zymogen granule membrane; Membrane raft. Secreted, after cleavage, in the pancreatic juice.

N-glycosylated.