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Rat Anti-GPM6A Recombinant Antibody (321) (CBMAB-G4602-LY)

This product is antibody recognizes GPM6A. The antibody 321 immunoassay techniques such as: IHC-F.
See all GPM6A antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
321
Antibody Isotype
IgG2a
Application
IHC-F

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GPM6A
Entrez Gene ID
234267
UniProt ID
P35802
Alternative Names
Gpm6; M6A
Function
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
Biological Process
Neural retina development Source: UniProtKB
Neuron migration Source: UniProtKB
Neuron projection development Source: GO_Central
Neuron projection morphogenesis Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Regulation of synapse organization Source: Ensembl
Response to bacterium Source: Ensembl
Stem cell differentiation Source: UniProtKB
Synapse assembly Source: UniProtKB
Cellular Location
Cell membrane; Axon; Growth cone; Dendritic spine; Filopodium; Neuron projection. Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (By similarity).
Topology
Cytoplasmic: 1-22
Helical: 23-43
Extracellular: 44-84
Helical: 85-105
Cytoplasmic: 106-127
Helical: 128-148
Extracellular: 149-213
Helical: 214-234
Cytoplasmic: 235-278
PTM
N-glycosylated.
Palmitoylated by ZDHHC17/HIP14.

Aparicio, G. I., León, A., Gutiérrez Fuster, R., Ravenscraft, B., Monje, P. V., & Scorticati, C. (2023). Endogenous Glycoprotein GPM6a Is Involved in Neurite Outgrowth in Rat Dorsal Root Ganglion Neurons. Biomolecules, 13(4), 594.

Alzuri, S. E., Rosas, N. M., Hlavacova, N., Jezova, D., & Fuchsova, B. (2023). Role of miR‐124‐3p in regulatory mechanisms of Gpm6a expression in the hippocampus of chronically stressed rats. Journal of Neurochemistry.

Narvel, H. G., Kim, S. Y., Shokrekhuda, A. M., Cohen, P. R., Ramesh, K. H., Solomon, S. R., ... & Halmos, B. (2023). Orthogonal Testing Unravels a Novel ROS1 Oncogenic Fusion Variant (ROS1-GPM6A): A Practical Approach to Molecular Testing for Actionable Fusion Variants. JCO precision oncology, 7, e2200593.

Liu, Y. M., Cao, Y., Zhao, P. S., Wu, L. Y., Lu, Y. M., Wang, Y. L., ... & Liu, X. G. (2022). CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway. International journal of biological sciences, 18(2), 637.

Li, Z. R., Xu, G., Zhu, L. Y., Chen, H., Zhu, J. M., & Wu, J. (2022). GPM6A expression is suppressed in hepatocellular carcinoma through miRNA-96 production. Laboratory Investigation, 102(11), 1280-1291.

Yunaini, L., & Khairat, E. (2022). Association of Variants in COMT, RASSF1 and GPM6A with the Risk of Paranoid Schizophrenia Patients in Prof HB Saanin Psychiatric Hospital, West Sumatra, Indonesia. The Malaysian Journal of Medical Sciences: MJMS, 29(2), 31.

Khalid, Z., & Sezerman, O. U. (2021). A comprehensive study on identifying the structural and functional SNPs of human neuronal membrane glycoprotein M6A (GPM6A). Journal of Biomolecular Structure and Dynamics, 39(8), 2693-2701.

Li, R. Z., Xu, G., Zhu, M. J., Wu, J., & Wu, J. (2020). Function and regulatory mechanism of GPM6A in hepatocellular carcinoma development and progression. Cancer Research, 80(16_Supplement), 5970-5970.

Rosas, N. M., Alvarez Juliá, A., Alzuri, S. E., Frasch, A. C., & Fuchsova, B. (2018). Alanine scanning mutagenesis of the C-terminal cytosolic end of Gpm6a identifies key residues essential for the formation of filopodia. Frontiers in molecular neuroscience, 11, 314.

Gu, X., Fu, C., Lin, L., Liu, S., Su, X., Li, A., ... & Wang, X. (2018). miR‐124 and miR‐9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C‐GPM6A pathway. Journal of Cellular Physiology, 233(1), 673-687.

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For research use only. Not intended for any clinical use.

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