GPM6A

Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.

Full Name

GPM6A

Function

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.

Biological Process

Neural retina development Source: UniProtKB
Neuron migration Source: UniProtKB
Neuron projection development Source: GO_Central
Neuron projection morphogenesis Source: UniProtKB
Positive regulation of filopodium assembly Source: UniProtKB
Regulation of synapse organization Source: Ensembl
Response to bacterium Source: Ensembl
Stem cell differentiation Source: UniProtKB
Synapse assembly Source: UniProtKB

Cellular Location

Cell membrane; Axon; Growth cone; Dendritic spine; Filopodium; Neuron projection. Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (By similarity).

Topology

Cytoplasmic: 1-22
Helical: 23-43
Extracellular: 44-84
Helical: 85-105
Cytoplasmic: 106-127
Helical: 128-148
Extracellular: 149-213
Helical: 214-234
Cytoplasmic: 235-278

PTM

N-glycosylated.
Palmitoylated by ZDHHC17/HIP14.