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Rabbit Anti-GPR151 Recombinant Antibody (EG1383) (CBMAB-EN1662-LY)

The product is antibody recognizes GPR151. The antibody EG1383 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000.
See all GPR151 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1383
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human GPR151.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 151
Introduction
This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]
Entrez Gene ID
134391
UniProt ID
Q8TDV0
Alternative Names
G Protein-Coupled Receptor 151; G-Protein Coupled Receptor PGR7; Galanin Receptor 4; GPCR-2037; PGR7; Probable G-Protein Coupled Receptor 151; GALR4; GALRL; GPCR;
Function
Proton-sensing G-protein coupled receptor.
Biological Process
G protein-coupled receptor signaling pathway Source: UniProtKB
Positive regulation of immune response Source: UniProtKB
Response to acidic pH Source: UniProtKB
Response to ischemia Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-41
Helical: 42-62
Cytoplasmic: 63-71
Helical: 72-92
Extracellular: 93-116
Helical: 117-137
Cytoplasmic: 138-153
Helical: 154-174
Extracellular: 175-201
Helical: 202-222
Cytoplasmic: 223-252
Helical: 253-273
Extracellular: 274-286
Helical: 287-307
Cytoplasmic: 308-419

Bielczyk-Maczynska, E., Zhao, M., Zushin, P. J. H., Schnurr, T. M., Kim, H. J., Li, J., ... & Knowles, J. W. (2022). G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis. Nature Communications, 13(1), 7408.

Förch, A., Wallner, S., Zeman, F., Ettl, T., Brochhausen, C., & Schreml, S. (2022). Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors. Cells, 11(1), 27.

Jiang, B. C., Zhang, J., Wu, B., Jiang, M., Cao, H., Wu, H., & Gao, Y. J. (2021). G protein–coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of Gβγ/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion. Pain, 162(5), 1434-1448.

Xia, L. P., Luo, H., Ma, Q., Xie, Y. K., Li, W., Hu, H., & Xu, Z. Z. (2021). GPR151 in nociceptors modulates neuropathic pain via regulating P2X3 function and microglial activation. Brain, 144(11), 3405-3420.

Antolin-Fontes, B., Li, K., Ables, J. L., Riad, M. H., Görlich, A., Williams, M., ... & Ibañez-Tallon, I. (2020). The habenular G-protein–coupled receptor 151 regulates synaptic plasticity and nicotine intake. Proceedings of the National Academy of Sciences, 117(10), 5502-5509.

Li, W. (2020). Ab Initio Modelling the Structure of Proton-Sensing G-Protein Coupled Receptor GPR151.

Jiang, B. C., Zhang, W. W., Yang, T., Guo, C. Y., Cao, D. L., Zhang, Z. J., & Gao, Y. J. (2018). Demethylation of G-protein-coupled receptor 151 promoter facilitates the binding of Krüppel-like factor 5 and enhances neuropathic pain after nerve injury in mice. Journal of Neuroscience, 38(49), 10535-10551.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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