GPR151

This gene encodes an orphan member of the class A rhodopsin-like family of G-protein-coupled receptors (GPCRs). Within the rhodopsin-like family, this gene is a member of the SOG subfamily that includes somatostatin, opioid, galanin, and kisspeptin receptors. The orthologous mouse gene has a restricted pattern of neuronal expression which is induced following nerve injury. All GPCRs have a transmembrane domain that includes seven transmembrane alpha-helices. A general feature of GPCR signaling is the agonist-induced conformational change in the receptor, leading to activation of the heterotrimeric G protein. The activated G protein then binds to and activates numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. [provided by RefSeq, Jul 2017]

Full Name

G Protein-Coupled Receptor 151

Function

Proton-sensing G-protein coupled receptor.

Biological Process

G protein-coupled receptor signaling pathway Source: UniProtKB
Positive regulation of immune response Source: UniProtKB
Response to acidic pH Source: UniProtKB
Response to ischemia Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 1-41
Helical: 42-62
Cytoplasmic: 63-71
Helical: 72-92
Extracellular: 93-116
Helical: 117-137
Cytoplasmic: 138-153
Helical: 154-174
Extracellular: 175-201
Helical: 202-222
Cytoplasmic: 223-252
Helical: 253-273
Extracellular: 274-286
Helical: 287-307
Cytoplasmic: 308-419