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Mouse Anti-GPR68 Recombinant Antibody (15B8) (CBMAB-G4666-LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
15B8
Application
ELISA, WB
Immunogen
Partial peptide of Human GPR68
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
G PROTEIN-COUPLED RECEPTOR 68
Introduction
The protein encoded by this gene is a G protein-coupled receptor for sphingosylphosphorylcholine. The encoded protein is a proton-sensing receptor, inactive at pH 7.8 but active at pH 6.8. Mutations in this gene are a cause of amelogenesis imperfecta. [provided by RefSeq, Feb 2017]
Entrez Gene ID
8111
UniProt ID
Q15743
Alternative Names
G Protein-Coupled Receptor 68; Sphingosylphosphorylcholine Receptor; GPR12A; OGR1; Ovarian Cancer G Protein-Coupled Receptor; 1; Ovarian Cancer G-Protein Coupled Receptor 1; G-Protein Coupled Receptor 68; AI2A6; OGR-1;
Function
Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).
Biological Process
Cellular response to pH Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
Inflammatory response Source: ProtInc
Negative regulation of monocyte differentiation Source: Ensembl
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Positive regulation of osteoclast development Source: Ensembl
Cellular Location
Cell membrane
Involvement in disease
Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6):
A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
Topology
Extracellular: 1-21
Helical: 22-46
Cytoplasmic: 47-58
Helical: 59-80
Extracellular: 81-95
Helical: 96-117
Cytoplasmic: 118-136
Helical: 137-158
Extracellular: 159-183
Helical: 184-205
Cytoplasmic: 206-228
Helical: 229-249
Extracellular: 250-263
Helical: 264-284
Cytoplasmic: 285-365

van Setten, G. B. (2023). Expression of GPR-68 in Human Corneal and Conjunctival Epithelium. Possible indicator and mediator of attrition associated inflammation at the ocular surface. Journal Français d'Ophtalmologie, 46(1), 19-24.

van Setten, G. B. (2022). GPR-68 in human lacrimal gland. Detection and possible role in the pathogenesis of dry eye disease. Journal Français d'Ophtalmologie, 45(8), 921-927.

de Vallière, C., Cosin-Roger, J., Baebler, K., Schoepflin, A., Mamie, C., Mollet, M., ... & Rogler, G. (2022). pH-sensing G protein-coupled receptor OGR1 (GPR68) expression and activation increases in intestinal inflammation and fibrosis. International Journal of Molecular Sciences, 23(3), 1419.

He, X., Feng, S., Hawkins, C., Lawley, L., Fan, W., Xu, Y., ... & Fang, J. (2020). G protein-coupled receptor 68 increases the number of B lymphocytes. American Journal of Blood Research, 10(2), 15.

Yu, X., Huang, X. P., Kenakin, T. P., Slocum, S. T., Chen, X., Martini, M. L., ... & Jin, J. (2019). Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68). Journal of medicinal chemistry, 62(16), 7557-7574.

Wiley, S. Z., Sriram, K., Salmerón, C., & Insel, P. A. (2019). GPR68: an emerging drug target in cancer. International journal of molecular sciences, 20(3), 559.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Request bulk or custom quote Second antibody and isotype control

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