Sign in or Register   Sign in or Register
  |  

Rabbit Anti-LPAR5 Recombinant Antibody (EG1411) (CBMAB-EN1690-LY)

The product is antibody recognizes GPR92. The antibody EG1411 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:1000.
See all LPAR5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1411
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR92.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lysophosphatidic acid receptor 5
Introduction
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.
Entrez Gene ID
57121
UniProt ID
Q9H1C0
Alternative Names
LPA5; GPR92; GPR93; KPG_010
Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
Biological Process
Behavioral response to painManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of CREB transcription factor activityManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-26
Helical: 27-47
Cytoplasmic: 48-55
Helical: 56-76
Extracellular: 77-96
Helical: 97-117
Cytoplasmic: 118-136
Helical: 137-157
Extracellular: 158-187
Helical: 188-208
Cytoplasmic: 209-239
Helical: 240-260
Extracellular: 261-276
Helical: 277-297
Cytoplasmic: 298-372

Dacheux, M. A., Norman, D. D., Tigyi, G. J., & Lee, S. C. (2023). Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer. Pharmacology & therapeutics, 108414.

Konen, J. M., Rodriguez, B. L., Wu, H., Fradette, J. J., Gibson, L., Diao, L., ... & Gibbons, D. L. (2023). Autotaxin suppresses cytotoxic T cells via LPAR5 to promote anti–PD-1 resistance in non–small cell lung cancer. Journal of Clinical Investigation, 133(17), e163128.

Sun, X. Y., Li, H. Z., Xie, D. F., Gao, S. S., Huang, X., Guan, H., ... & Zhou, P. K. (2022). LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway. Journal of Translational Medicine, 20(1), 1-16.

Langedijk, J., Araya, E. I., Barroso, A. R., Tolenaars, D., Nazaré, M., Belabed, H., ... & Oude Elferink, R. (2022). An LPAR5-antagonist that reduces nociception and increases pruriception. Frontiers in Pain Research, 3, 963174.

Zhao, W. J., Zhu, L. L., Yang, W. Q., Xu, S. J., Chen, J., Ding, X. F., ... & Chen, G. (2021). LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β. Cancer Science, 112(4), 1624-1632.

Zheng, Y. Q., Miao, X., Li, J., Hu, M. F., Zhu, Y. S., Li, X. R., & Zhang, Y. J. (2020). Trichostatin A alleviates the process of breast carcinoma by downregulating LPAR5. European Review for Medical & Pharmacological Sciences, 24(11).

Zhang, H. P., Chen, Q. K., & Xu, J. F. (2020). LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11. European Review for Medical & Pharmacological Sciences, 24(17).

Sumitomo, A., Siriwach, R., Thumkeo, D., Ito, K., Nakagawa, R., Tanaka, N., ... & Narumiya, S. (2019). LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPAR5-RHO-ROCK-SRF axis. Journal of Investigative Dermatology, 139(5), 1010-1022.

Plastira, I., Joshi, L., Bernhart, E., Schoene, J., Specker, E., Nazare, M., & Sattler, W. (2019). Small-molecule lysophosphatidic acid receptor 5 (LPAR5) antagonists: versatile pharmacological tools to regulate inflammatory signaling in BV-2 microglia cells. Frontiers in Cellular Neuroscience, 13, 531.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-LPAR5 Recombinant Antibody (EG1411)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare