Rabbit Anti-LPAR5 Recombinant Antibody (EG1411) (CBMAB-EN1690-LY)

Name: Rabbit Anti-LPAR5 Recombinant Antibody (EG1411)
SKU: CBMAB-EN1690-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EG1411

Application

WB: 1:500~1:1000 ELISA: 1:1000

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GPR92.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

lysophosphatidic acid receptor 5

Introduction

This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.

Entrez Gene ID

57121

UniProt ID

Q9H1C0

Alternative Names

LPA5; GPR92; GPR93; KPG_010

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Biological Process

Behavioral response to painManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of CREB transcription factor activityManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-26
Helical: 27-47
Cytoplasmic: 48-55
Helical: 56-76
Extracellular: 77-96
Helical: 97-117
Cytoplasmic: 118-136
Helical: 137-157
Extracellular: 158-187
Helical: 188-208
Cytoplasmic: 209-239
Helical: 240-260
Extracellular: 261-276
Helical: 277-297
Cytoplasmic: 298-372

Dacheux, M. A., Norman, D. D., Tigyi, G. J., & Lee, S. C. (2023). Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer. Pharmacology & therapeutics, 108414.

Konen, J. M., Rodriguez, B. L., Wu, H., Fradette, J. J., Gibson, L., Diao, L., ... & Gibbons, D. L. (2023). Autotaxin suppresses cytotoxic T cells via LPAR5 to promote anti–PD-1 resistance in non–small cell lung cancer. Journal of Clinical Investigation, 133(17), e163128.

Sun, X. Y., Li, H. Z., Xie, D. F., Gao, S. S., Huang, X., Guan, H., ... & Zhou, P. K. (2022). LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway. Journal of Translational Medicine, 20(1), 1-16.

Langedijk, J., Araya, E. I., Barroso, A. R., Tolenaars, D., Nazaré, M., Belabed, H., ... & Oude Elferink, R. (2022). An LPAR5-antagonist that reduces nociception and increases pruriception. Frontiers in Pain Research, 3, 963174.

Zhao, W. J., Zhu, L. L., Yang, W. Q., Xu, S. J., Chen, J., Ding, X. F., ... & Chen, G. (2021). LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β. Cancer Science, 112(4), 1624-1632.

Zheng, Y. Q., Miao, X., Li, J., Hu, M. F., Zhu, Y. S., Li, X. R., & Zhang, Y. J. (2020). Trichostatin A alleviates the process of breast carcinoma by downregulating LPAR5. European Review for Medical & Pharmacological Sciences, 24(11).

Zhang, H. P., Chen, Q. K., & Xu, J. F. (2020). LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11. European Review for Medical & Pharmacological Sciences, 24(17).

Sumitomo, A., Siriwach, R., Thumkeo, D., Ito, K., Nakagawa, R., Tanaka, N., ... & Narumiya, S. (2019). LPA induces keratinocyte differentiation and promotes skin barrier function through the LPAR1/LPAR5-RHO-ROCK-SRF axis. Journal of Investigative Dermatology, 139(5), 1010-1022.

Plastira, I., Joshi, L., Bernhart, E., Schoene, J., Specker, E., Nazare, M., & Sattler, W. (2019). Small-molecule lysophosphatidic acid receptor 5 (LPAR5) antagonists: versatile pharmacological tools to regulate inflammatory signaling in BV-2 microglia cells. Frontiers in Cellular Neuroscience, 13, 531.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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