LPAR5

This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.

Full Name

lysophosphatidic acid receptor 5

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

Biological Process

Behavioral response to painManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of CREB transcription factor activityManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-26
Helical: 27-47
Cytoplasmic: 48-55
Helical: 56-76
Extracellular: 77-96
Helical: 97-117
Cytoplasmic: 118-136
Helical: 137-157
Extracellular: 158-187
Helical: 188-208
Cytoplasmic: 209-239
Helical: 240-260
Extracellular: 261-276
Helical: 277-297
Cytoplasmic: 298-372