Mouse Anti-GRIK2 Recombinant Antibody (CBT3718) (V2LY-0625-LY742)
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Basic Information
| Application | Note |
| WB | 1:500-1:2,000 |
| ELISA | 1:10,000 |
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Modulates cell surface expression of NETO2 (By similarity).
Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366).
Functions in dorsal root ganglion neurons (By similarity).
Detection of cold stimulus involved in thermoception Source: UniProtKB
Glutamate receptor signaling pathway Source: ProtInc
Modulation of chemical synaptic transmission Source: UniProtKB
Positive regulation of synaptic transmission Source: UniProtKB
Regulation of short-term neuronal synaptic plasticity Source: UniProtKB
Synaptic transmission, glutamatergic Source: GO_Central
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal.
Helical: 562-582
Cytoplasmic: 583-635
Helical: 636-656
Extracellular: 657-819
Helical: 820-840
Cytoplasmic: 841-908
Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity).
Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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