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Rabbit Anti-GRIK2 Recombinant Antibody (BA0310) (CBMAB-0354CQ)

This product is a rabbit antibody that recognizes GRIK2. The antibody BA0310 can be used for immunoassay techniques such as: IHC-P, WB.
See all GRIK2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0310
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide from residues in the extracellular domain of Human GRIK2
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glutamate Ionotropic Receptor Kainate Type Subunit 2
Introduction
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The GRIK2 gene comprises 16 exons. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Using PCR analysis of rodent/human monochromosomal cell lines. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation.
Entrez Gene ID
Human2898
Mouse14806
Rat54257
UniProt ID
HumanQ13002
MouseP39087
RatP42260
Alternative Names
EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2
Function
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184).

Modulates cell surface expression of NETO2 (By similarity).

Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366).

Functions in dorsal root ganglion neurons (By similarity).
Biological Process
Chemical synaptic transmission Source: ProtInc
Detection of cold stimulus involved in thermoception Source: UniProtKB
Glutamate receptor signaling pathway Source: ProtInc
Modulation of chemical synaptic transmission Source: UniProtKB
Positive regulation of synaptic transmission Source: UniProtKB
Regulation of short-term neuronal synaptic plasticity Source: UniProtKB
Synaptic transmission, glutamatergic Source: GO_Central
Cellular Location
Cell membrane; Postsynaptic cell membrane
Involvement in disease
Mental retardation, autosomal recessive 6 (MRT6):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal.
Topology
Extracellular: 32-561
Helical: 562-582
Cytoplasmic: 583-635
Helical: 636-656
Extracellular: 657-819
Helical: 820-840
Cytoplasmic: 841-908
PTM
Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 (By similarity).
Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity).
Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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