Mouse Anti-GSTA4 Recombinant Antibody (3F5) (CBMAB-G5472-LY)

Name: Mouse Anti-GSTA4 Recombinant Antibody (3F5)
SKU: CBMAB-G5472-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3F5

Application

WB, IHC, FC

Immunogen

Full length human recombinant protein of human GSTA4.

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, BSA, glycerol

Preservative

Sodium azide

Concentration

1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glutathione S-Transferase Alpha 4

Introduction

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]

Entrez Gene ID

2941

UniProt ID

O15217

Alternative Names

Glutathione S-Transferase Alpha 4; Glutathione S-Transferase A4-4; Glutathione S-Transferase A4; GST Class-Alpha Member 4; EC 2.5.1.18; S-(Hydroxyalkyl)Glutathione Lyase A4; Glutathione S-Aralkyltransferase A4;

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal (4-HNE).

Biological Process

Glutathione metabolic process Source: UniProtKB
Xenobiotic metabolic process Source: UniProtKB

Cellular Location

Cytoplasm

Ucche, S., Yokoyama, S., Mojic, M., Oki, K., Ohshima, C., Tsuihiji, H., ... & Hayakawa, Y. (2023). GSTA4 governs melanoma immune resistance and metastasis. Molecular Cancer Research, 21(1), 76-85.

Carlström, K. E., Zhu, K., Ewing, E., Krabbendam, I. E., Harris, R. A., Falcão, A. M., ... & Piehl, F. (2020). Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis. Nature communications, 11(1), 4071.

Park, H. J., Kim, M. J., Han, C., White, K., Ding, D., Boyd, K., ... & Someya, S. (2020). Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice. Experimental gerontology, 133, 110872.

Park, H. J., Kim, M. J., Rothenberger, C., Kumar, A., Sampson, E. M., Ding, D., ... & Someya, S. (2019). GSTA4 mediates reduction of cisplatin ototoxicity in female mice. Nature communications, 10(1), 4150.

Shearn, C. T., Pulliam, C. F., Pedersen, K., Meredith, K., Mercer, K. E., Saba, L. M., ... & Petersen, D. R. (2018). Knockout of the Gsta4 gene in male mice leads to an altered pattern of hepatic protein carbonylation and enhanced inflammation following chronic consumption of an ethanol diet. Alcoholism: Clinical and Experimental Research, 42(7), 1192-1205.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

GSTA4 Matched Antibody Pair (508) (CAT#: APMAB-508LY)

Related Products

Rabbit Anti-GSTA4 Recombinant Antibody (1E2) (CAT#: CBMAB-G5471-LY)

GSTA4 Matched Antibody Pair (508) (CAT#: APMAB-508LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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