GSTA4 Matched Antibody Pair (508) (APMAB-508LY)

Name: GSTA4 Matched Antibody Pair (508)
SKU: APMAB-508LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet References Q & As Review & reward Protocols Associated Products

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-GSTA4 polyclonal antibody, 100 ug

Detection Antibody

Anti-GSTA4 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]

Alternative Names

Glutathione S-Transferase Alpha 4; Glutathione S-Transferase A4-4; Glutathione S-Transferase A4; GST Class-Alpha Member 4; EC 2.5.1.18; S-(Hydroxyalkyl)Glutathione Lyase A4; Glutathione S-Aralkyltransferase A4;

Entrez Gene ID

2941

UniProt ID

O15217

More Infomation

Ucche, S., Yokoyama, S., Mojic, M., Oki, K., Ohshima, C., Tsuihiji, H., ... & Hayakawa, Y. (2023). GSTA4 governs melanoma immune resistance and metastasis. Molecular Cancer Research, 21(1), 76-85.

Carlström, K. E., Zhu, K., Ewing, E., Krabbendam, I. E., Harris, R. A., Falcão, A. M., ... & Piehl, F. (2020). Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis. Nature communications, 11(1), 4071.

Park, H. J., Kim, M. J., Han, C., White, K., Ding, D., Boyd, K., ... & Someya, S. (2020). Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice. Experimental gerontology, 133, 110872.

Park, H. J., Kim, M. J., Rothenberger, C., Kumar, A., Sampson, E. M., Ding, D., ... & Someya, S. (2019). GSTA4 mediates reduction of cisplatin ototoxicity in female mice. Nature communications, 10(1), 4150.

Shearn, C. T., Pulliam, C. F., Pedersen, K., Meredith, K., Mercer, K. E., Saba, L. M., ... & Petersen, D. R. (2018). Knockout of the Gsta4 gene in male mice leads to an altered pattern of hepatic protein carbonylation and enhanced inflammation following chronic consumption of an ethanol diet. Alcoholism: Clinical and Experimental Research, 42(7), 1192-1205.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-GSTA4 Recombinant Antibody (3F5) (CAT#: CBMAB-G5472-LY)

Rabbit Anti-GSTA4 Recombinant Antibody (1E2) (CAT#: CBMAB-G5471-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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