Mouse Anti-H2-D1 Recombinant Antibody (CBFYH-3350) (CBMAB-H0424-FY)

Name: Mouse Anti-H2-D1 Recombinant Antibody (CBFYH-3350)
SKU: CBMAB-H0424-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-3350

Application

Immunogen

C3H.SW mouse splenocytes1, 2

Specificity

Mouse

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Histocompatibility 2, D Region Locus 1

Introduction

The genes at the H-2D region only (B10.BR → B6AF1), at the H-2K region only (B10.D2 → B6AF1), at loci other than H-2 (129 → B/10); and at H-2D, H-2K, and non-H-2 loci (A → (129 X B/10)F1).

Entrez Gene ID

14964

UniProt ID

P01899

Alternative Names

H-2D; H2-D; H2-K1

Function

Involved in the presentation of foreign antigens to the immune system.

Biological Process

Antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
Immune response Source: InterPro
Negative regulation of neuron projection development Source: MGI
Positive regulation of T cell mediated cytotoxicity Source: MGI

Cellular Location

Membrane

Topology

Extracellular: 25-309
Helical: 310-331
Cytoplasmic: 332-362

PTM

Polyubiquitinated in case of infection by murid herpesvirus 4, by the viral E3 ligase K3 (mK3). This modification causes the protein to be targeted for rapid degradation by the endoplasmic reticulum-associated degradation (ERAD) system. Ubiquitination occurs on lysine, as well as serine and threonine residues present in the cytoplasmic tail. Serine and threonine residues are subject to ubiquitination via ester bonds instead of the usual isopeptide linkage.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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