H2-D1

The genes at the H-2D region only (B10.BR → B6AF1), at the H-2K region only (B10.D2 → B6AF1), at loci other than H-2 (129 → B/10); and at H-2D, H-2K, and non-H-2 loci (A → (129 X B/10)F1).

Full Name

Histocompatibility 2, D Region Locus 1

Function

Involved in the presentation of foreign antigens to the immune system.

Biological Process

Antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
Immune response Source: InterPro
Negative regulation of neuron projection development Source: MGI
Positive regulation of T cell mediated cytotoxicity Source: MGI

Cellular Location

Membrane

Topology

Extracellular: 25-309
Helical: 310-331
Cytoplasmic: 332-362

PTM

Polyubiquitinated in case of infection by murid herpesvirus 4, by the viral E3 ligase K3 (mK3). This modification causes the protein to be targeted for rapid degradation by the endoplasmic reticulum-associated degradation (ERAD) system. Ubiquitination occurs on lysine, as well as serine and threonine residues present in the cytoplasmic tail. Serine and threonine residues are subject to ubiquitination via ester bonds instead of the usual isopeptide linkage.