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Mouse Anti-H6PD Recombinant Antibody (2A7) (CBMAB-G5989-LY)

This product is antibody recognizes H6PD. The antibody 2A7 immunoassay techniques such as: WB.
See all H6PD antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
2A7
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human H6PD (NP_004276) produced in HEK293T cell
Specificity
Human, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Introduction
There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human9563
Monkey710107
UniProt ID
HumanO95479
MonkeyF6VEC2
Alternative Names
Hexose-6-Phosphate Dehydrogenase/Glucose 1-Dehydrogenase; GDH/6PGL Endoplasmic Bifunctional Protein; Glucose Dehyrogenase; GDH; Hexose-6-Phosphate Dehydrogenase (Glucose 1-Dehydrogenase); Glucose-6-Phosphate Dehydrogenase; Salivary; -Phosphogluconolactonase; Glucose 1- Dehydrogenase;
Function
Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity).

Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12858176, PubMed:18628520, PubMed:23132696).

In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity).

May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity).

The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12858176, PubMed:18628520, PubMed:23132696).

By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:18628520).
Biological Process
Glucose metabolic process Source: UniProtKB-KW
Pentose-phosphate shunt, oxidative branch Source: UniProtKB
Regulation of cortisol biosynthetic process Source: UniProtKB
Response to alcohol Source: Ensembl
Cellular Location
Endoplasmic reticulum lumen
Involvement in disease
Cortisone reductase deficiency 1 (CORTRD1):
An autosomal recessive error of cortisone metabolism characterized by a failure to regenerate cortisol from cortisone, resulting in increased cortisol clearance, activation of the hypothalamic-pituitary axis and ACTH-mediated adrenal androgen excess. Clinical features include hyperandrogenism resulting in hirsutism, oligo-amenorrhea, and infertility in females and premature pseudopuberty in males.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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