Mouse Anti-H6PD Recombinant Antibody (CBFYH-0638) (CBMAB-H1521-FY)

Name: Mouse Anti-H6PD Recombinant Antibody (CBFYH-0638)
SKU: CBMAB-H1521-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-0638

Application

WB, IHC-P, FC, IF

Specificity

Human, Monkey

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)

Introduction

There are 2 forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells.

Entrez Gene ID

Human	9563
Monkey	710107

UniProt ID

Human	O95479
Monkey	F6VEC2

Alternative Names

Hexose-6-Phosphate Dehydrogenase/Glucose 1-Dehydrogenase; GDH/6PGL Endoplasmic Bifunctional Protein; Glucose Dehyrogenase; GDH; Hexose-6-Phosphate Dehydrogenase (Glucose 1-Dehydrogenase); Glucose-6-Phosphate Dehydrogenase, Salivary; -Phosphogluconolactonase; Glucose 1- Dehydrogenase

Function

Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity).

Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway (PubMed:12858176, PubMed:18628520, PubMed:23132696).

In addition, acts as a 6-phosphogluconolactonase and catalyzes the second step of the pentose phosphate pathway (By similarity).

May have a dehydrogenase activity for alternative substrates including glucosamine 6-phosphate and glucose 6-sulfate (By similarity).

The main function of this enzyme is to provide reducing equivalents such as NADPH to maintain the adequate levels of reductive cofactors in the oxidizing environment of the endoplasmic reticulum (PubMed:12858176, PubMed:18628520, PubMed:23132696).

By producing NADPH that is needed by reductases of the lumen of the endoplasmic reticulum like corticosteroid 11-beta-dehydrogenase isozyme 1/HSD11B1, indirectly regulates their activity (PubMed:18628520).

Biological Process

Glucose metabolic process Source: UniProtKB-KW
Pentose-phosphate shunt, oxidative branch Source: UniProtKB
Regulation of cortisol biosynthetic process Source: UniProtKB
Response to alcohol Source: Ensembl

Cellular Location

Endoplasmic reticulum lumen

Involvement in disease

Cortisone reductase deficiency 1 (CORTRD1):
An autosomal recessive error of cortisone metabolism characterized by a failure to regenerate cortisol from cortisone, resulting in increased cortisol clearance, activation of the hypothalamic-pituitary axis and ACTH-mediated adrenal androgen excess. Clinical features include hyperandrogenism resulting in hirsutism, oligo-amenorrhea, and infertility in females and premature pseudopuberty in males.

Zhang, Y. B., Zheng, S. F., Ma, L. J., Lin, P., Shang-Guan, H. C., Lin, Y. X., ... & Yao, P. S. (2022). Elevated Hexose-6-Phosphate Dehydrogenase Regulated by OSMR-AS1/hsa-miR-516b-5p Axis Correlates with Poor Prognosis and Dendritic Cells Infiltration of Glioblastoma. Brain Sciences, 12(8), 1012.

Naseri, R., Alimoradi, Y., Maryam, S., Fard, M. C., Barzingarosi, E., Abdolmaleki, A., & Jalili, C. (2022). H6PD gene polymorphisms (R453Q and D151A) and polycystic ovary syndrome: A case-control study in a population of Iranian Kurdish Women. International Journal of Fertility & Sterility, 16(3), 180.

Xiu, C., Song, R., & Jiang, J. (2021). TUG1 promotes retinoblastoma progression by sponging miR-516b-5p to upregulate H6PD expression. Translational Cancer Research, 10(2), 738.

Tsachaki, M., Mladenovic, N., Štambergová, H., Birk, J., & Odermatt, A. (2018). Hexose-6-phosphate dehydrogenase controls cancer cell proliferation and migration through pleiotropic effects on the unfolded-protein response, calcium homeostasis, and redox balance. The FASEB Journal, 32(5), 2690.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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