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Rat Anti-Havcr2 Recombinant Antibody (RMT3-23) (CBMAB-T0384-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Havcr2 (Hepatitis A Virus Cellular Receptor 2). The antibody can be used for immunoassay techniques, such as FC, IF, IHC.
Host Species
Rat
Application
FC, IF, IHC
Immunogen
Tim-3-Ig, consisting of aa1-191 from mouse Tim-3, coupled with the Fc portion of mouse IgG2a
Antibody Isotype
IgG2a
Specificity
Mouse
Cross Reactivity
Mouse
Clone
RMT3-23
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
Havcr2 is a cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand.
Alternative Name
Tim3; TIM-3; Timd3
Entrez Gene ID
UniProt ID

This product has been referenced in:

Hou, N., Jiang, N., Zou, Y., Piao, X., Liu, S., Li, S., & Chen, Q. (2017). Down-regulation of Tim-3 in monocytes and macrophages in plasmodium infection and its association with parasite clearance. Frontiers in microbiology, 8, 1431.

Chen, L., Yi, X., Goswami, S., Ahn, Y. H., Roybal, J. D., Yang, Y., ... & Wang, J. (2016). Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression. Oncoimmunology, 5(11), e1234570.

Hou, N., Piao, X., Liu, S., Wu, C., & Chen, Q. (2015). Tim-3 induces Th2-biased immunity and alternative macrophage activation during Schistosoma japonicum infection. Infection and immunity, 83(8), 3074-3082.

Nakayama, M., Akiba, H., Takeda, K., Kojima, Y., Hashiguchi, M., Azuma, M., ... & Okumura, K. (2009). Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood, 113(16), 3821-3830.

Hou, N., Piao, X., Liu, S., Wu, C., & Chen, Q. (2015). Tim-3 induces Th2-biased immunity and alternative macrophage activation during Schistosoma japonicum infection. Infection and immunity, 83(8), 3074-3082.

Nakayama, M., Akiba, H., Takeda, K., Kojima, Y., Hashiguchi, M., Azuma, M., ... & Okumura, K. (2009). Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation. Blood, 113(16), 3821-3830.

Hou, N., Jiang, N., Zou, Y., Piao, X., Liu, S., Li, S., & Chen, Q. (2017). Down-regulation of Tim-3 in monocytes and macrophages in plasmodium infection and its association with parasite clearance. Frontiers in microbiology, 8, 1431.

Cat CBMAB-T0384-YJ
Conjugates
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