Mouse Anti-HBEGF Recombinant Antibody (CBFYH-0747) (CBMAB-H0355-FY)

Name: Mouse Anti-HBEGF Recombinant Antibody (CBFYH-0747)
SKU: CBMAB-H0355-FY
Rating: 5 (1 reviews)

See all HBEGF antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-0747

Application

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human HB-EGF, Asp63-Leu148

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

heparin-binding EGF-like growth factor

Introduction

HBEGF (Heparin Binding EGF Like Growth Factor) is a Protein Coding gene. Diseases associated with HBEGF include Diphtheria and Bladder Disease. Among its related pathways are RET signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include growth factor activity and epidermal growth factor receptor binding. An important paralog of this gene is AREG.

Entrez Gene ID

1839

UniProt ID

Q99075

Alternative Names

Heparin Binding EGF Like Growth Factor; Diphtheria Toxin Receptor (Heparin-Binding Epidermal Growth Factor-Like Growth Factor); Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor); Heparin-Binding Epidermal Growth Factor; HEGFL; DTR

Function

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Biological Process

Cell chemotaxis Source: UniProtKB
Epidermal growth factor receptor signaling pathway Source: BHF-UCL
Muscle organ development Source: ProtInc
Negative regulation of elastin biosynthetic process Source: Ensembl
Positive regulation of cell growth Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of epidermal growth factor-activated receptor activity Source: GO_Central
Positive regulation of keratinocyte migration Source: Ensembl
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Positive regulation of wound healing Source: BHF-UCL
Regulation of heart contraction Source: Ensembl
Signal transduction Source: ProtInc
Wound healing, spreading of epidermal cells Source: Ensembl

Cellular Location

Heparin-binding EGF-like growth factor: Extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.
Proheparin-binding EGF-like growth factor: Cell membrane

Topology

Extracellular: 20-160
Helical: 161-184
Cytoplasmic: 185-208

PTM

Several N-termini have been identified by direct sequencing. The forms with N-termini 63, 73 and 74 have been tested and found to be biologically active.
O-glycosylated with core 1 or possibly core 8 glycans. Thr-47 is a minor glycosylation site compared to Thr-44.

Kim, Y. S., Yuan, J., Dewar, A., Borg, J. P., Threadgill, D. W., Sun, X., & Dey, S. K. (2023). An unanticipated discourse of HB-EGF with VANGL2 signaling during embryo implantation. Proceedings of the National Academy of Sciences, 120(20), e2302937120.

Zhou, L., Zhou, W., Joseph, A. M., Chu, C., Putzel, G. G., Fang, B., ... & Sonnenberg, G. F. (2022). Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nature immunology, 23(2), 251-261.

Yi, L., Ai, K., Li, H., Qiu, S., Li, Y., Wang, Y., ... & Zhang, D. (2021). CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis. Aging (Albany NY), 13(9), 12780.

Li, Y., Su, G., Zhong, Y., Xiong, Z., Huang, T., Quan, J., ... & Lai, T. (2021). HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration. BMC Pulmonary Medicine, 21(1), 1-12.

Rao, L., Giannico, D., Leone, P., Solimando, A. G., Maiorano, E., Caporusso, C., ... & Racanelli, V. (2020). HB-EGF–EGFR signaling in bone marrow endothelial cells mediates angiogenesis associated with multiple myeloma. Cancers, 12(1), 173.

Fu, E., Liu, T., Yu, S., Chen, X., Song, L., Lou, H., ... & Wei, L. (2020). M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB‑EGF. Oncology Reports, 44(2), 698-710.

Eapen, M. S., Sharma, P., Thompson, I. E., Lu, W., Myers, S., Hansbro, P. M., & Sohal, S. S. (2019). Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies. Laboratory Investigation, 99(2), 150-157.

Wen, H. J., Gao, S., Wang, Y., Ray, M., Magnuson, M. A., Wright, C. V., ... & Crawford, H. C. (2019). Myeloid cell-derived HB-EGF drives tissue recovery after pancreatitis. Cellular and Molecular Gastroenterology and Hepatology, 8(2), 173-192.

Yang, C. C., & Chang, K. W. (2018). Eicosanoids and HB-EGF/EGFR in cancer. Cancer and Metastasis Reviews, 37, 385-395.

Wang, H. U. I., Shi, G., Li, M., Fan, H., Ma, H., & Sheng, L. I. (2018). Correlation of IL-1 and HB-EGF with endometrial receptivity. Experimental and therapeutic medicine, 16(6), 5130-5136.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-HBEGF Recombinant Antibody (CBFYH-0747)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Human Anti-HBEGF Recombinant Antibody (CBFYH-0748) (CAT#: CBMAB-H1651-FY)

Mouse Anti-HBEGF (AA 20-208) Recombinant Antibody (CBFYH-0750) (CAT#: CBMAB-H1653-FY)

Mouse Anti-HBEGF Recombinant Antibody (CBFYH-0749) (CAT#: CBMAB-H1652-FY)

Mouse Anti-HBEGF Recombinant Antibody (CBFYH-0746) (CAT#: CBMAB-H1650-FY)

Mouse Anti-HBEGF Recombinant Antibody (1A4) (CAT#: CBMAB-A3753-LY)

Mouse Anti-HBEGF (AA 63-148) Recombinant Antibody (CBFYH-0745) (CAT#: CBMAB-H1649-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry