Mouse Anti-HBG2 Recombinant Antibody (CBFYH-2872) (CBMAB-H1658-FY)

Name: Mouse Anti-HBG2 Recombinant Antibody (CBFYH-2872)
SKU: CBMAB-H1658-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYH-2872

Application

ELISA, LFI

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Hemoglobin Subunit Gamma 2

Introduction

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Entrez Gene ID

3048

UniProt ID

P69892

Alternative Names

Hemoglobin Subunit Gamma 2; Hemoglobin Gamma-2 Chain; Hemoglobin Gamma-G Chain; Hemoglobin, Gamma G; Gamma-2-Globin; Hb F Ggamma; Hemoglobin Subunit Gamma-2

Function

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Biological Process

Cellular oxidant detoxification Source: GOC
Hydrogen peroxide catabolic process Source: GO_Central

Cellular Location

Cytosol; Hemoglobin complex; Blood microparticle; Haptoglobin-hemoglobin complex

Involvement in disease

Cyanosis transient neonatal (TNCY):
A disorder characterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reduced affinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain is produced and replaces the fetal gamma-globin chain.

PTM

Acetylation of Gly-2 converts Hb F to the minor Hb F1.

Mohammad, S. N. N. A. I., Iberahim, S., Wan Ab Rahman, W. S., Hassan, M. N., Edinur, H. A., Azlan, M., & Zulkafli, Z. (2022). Single Nucleotide Polymorphisms in XMN1-HBG2, HBS1L-MYB, and BCL11A and Their Relation to High Fetal Hemoglobin Levels That Alleviate Anemia. Diagnostics, 12(6), 1374.

Métais, J. Y., Doerfler, P. A., Mayuranathan, T., Bauer, D. E., Fowler, S. C., Hsieh, M. M., ... & Weiss, M. J. (2019). Genome editing of HBG1 and HBG2 to induce fetal hemoglobin. Blood advances, 3(21), 3379-3392.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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