Sign in or Register   Sign in or Register
  |  

Mouse Anti-HBG2 Recombinant Antibody (CBXF-1984) (CBMAB-F0517-CQ)

This product is a mouse antibody that recognizes HBG2. The antibody CBXF-1984 can be used for immunoassay techniques such as: FC.
See all HBG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1984
Antibody Isotype
IgG1, κ
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Hemoglobin Subunit Gamma 2
Introduction
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'- epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Entrez Gene ID
3048
UniProt ID
P69892
Alternative Names
Hemoglobin Subunit Gamma 2; Hemoglobin Gamma-2 Chain; Hemoglobin Gamma-G Chain; Hemoglobin, Gamma G; Gamma-2-Globin; Hb F Ggamma; Hemoglobin Subunit Gamma-2;
Function
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Biological Process
Cellular oxidant detoxification Source: GOC
Hydrogen peroxide catabolic process Source: GO_Central
Cellular Location
Cytosol; Hemoglobin complex; Blood microparticle; Haptoglobin-hemoglobin complex
Involvement in disease
Cyanosis transient neonatal (TNCY):
A disorder characterized by cyanosis in the fetus and neonate, due to a defect in the fetal hemoglobin chain which has reduced affinity for oxygen. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain is produced and replaces the fetal gamma-globin chain.
PTM
Acetylation of Gly-2 converts Hb F to the minor Hb F1.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-HBG2 Recombinant Antibody (CBXF-1984)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare